Using autologous chondrocyte suspension for knee cartilage repair

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study evaluates the effectiveness and safety of autologous chondrocyte suspension in treating knee articular cartilage defects. Participants will undergo a biopsy for cell production, followed by cell implantation and a strict rehabilitation protocol over 12 months. Assessments will include MRI evaluations, collection of adverse events, and orthopedic scores at multiple follow-up intervals (6 weeks, 3 months, 6 months, and 12 months). Informed consent is obtained from all participants prior to the procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 15 and 50.
2. Lesions classified as ICRS Grade III or IV and smaller than 15 cm2
3. Lesions that have failed prior therapy (conservative or surgical treatment ≥ six months)
4. Subjects who understand and sign the consent form for this study

Exclusion Criteria:

1. Body mass index (BMI) of 35 or more
2. Osteoarthritis or rheumatoid arthritis
3. Diffuse lesion
4. Uncorrected mal-alignment, ligamentous instability, or meniscal tear
5. Presence of growth cartilage (15-18 years old)
6. Active smoking or drug consumption
7. Women who are pregnant
8. Positive serology for HIV-1 or HIV-2, Hepatitis B and C and syphilis
9. Proven allergy to porcine collagen, penicillin and gentamicin
10. Poor compliance

Where it's running

• Centre Hospitalier Universitaire Vaudois - CHUV
  Lausanne, Canton of Vaud, Switzerland Recruiting

Study contacts

• Principal investigator: Robin MARTIN, MD — Chuv
• Study coordinator: Robin MARTIN, MD
• Email: robin.martin@chuv.ch
• Phone: 021 314 76 79

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.