Using ATP to improve depression symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical study is a randomized, double-blind, placebo-controlled trial designed to evaluate the effectiveness of adenosine disodium triphosphate (ATP) in conjunction with escitalopram for treating moderate to severe depression. A total of 120 participants will be recruited and randomly assigned to either the ATP group or a control group receiving a placebo. The study will assess changes in depression severity using the Hamilton Depression Scale (HAMD-24) and other cognitive and inflammatory markers over a 4-week intervention period. The aim is to determine if ATP can enhance the therapeutic effects of escitalopram in depressed patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meet the diagnostic and statistical manual of mental disorders-5 diagnostic criteria for moderate to severe depression.
* HAMD-24 scores ≥ 20.
* 18-65 female or male.
* Participants who have not used any psychotropic medications within one month prior to study and never had a treatment with escitalopram.
* Individuals without contraindications to selective serotonin reuptake inhibitor.
* Individuals without contraindications to ATP.
* Written informed consent.

Exclusion Criteria:

* Participants with various major mental disorders other than depression (bipolar disorder, any psychotic disorder, Personality Disorders, alcohol use disorder, substance use disorder, and disorders due to medical or organic cause) assessed using Chinese version of the Mini International Neuropsychiatric Interview (MINI).
* Individuals with neurological disorders such as dementia.
* Individuals with a high risk of suicide.
* Pregnant and lactating women.
* Contraindications to MRI.
* Physician evaluation was not suitable for participants in this study.

Where it's running

• Nanfang Hospital, Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Bin Zhang, PhD
• Email: zhang73bin@hotmail.com
• Phone: 86-020-62786731

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.