Using antibiotics to prevent infections after jaw surgery
Official title: The Use of Single Dose vs Short-Term Peri-Operative Cefazolin in the Prevention of Surgical Site Infection Following Orthognathic Surgery
Run by Nova Scotia Health Authority · NCT05852158 · Data updated 2026-11-12
This study tests whether giving antibiotics before and after jaw surgery can help prevent infections in patients who are having surgery to fix jaw and facial problems.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 16 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Nova Scotia Health Authority Academic / other |
| Locations | 1 site (Halifax, Nova Scotia) |
| Status | Recruiting |
| Started | January 9, 2024 |
| Main results expected | January 2027 |
| Study ends | July 2027 |
| Registry record updated | March 19, 2026 |
| Trial ID | NCT05852158 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients aged 16 and older with ASA physical status classifications 1 and 2 who are scheduled for orthognathic surgery.
✕Probably not a fit
Patients with ASA classifications 3 and higher, recent antibiotic use, or those with systemic infections or immunosuppression may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of peri-operative antibiotics in reducing the incidence of surgical site infections (SSIs) following orthognathic surgery, which aims to correct jaw and facial deformities. The study will involve administering Cefazolin injections to patients undergoing these procedures, focusing on optimizing antibiotic protocols to minimize infection rates. Participants will be monitored for SSI occurrences post-surgery to evaluate the impact of the antibiotic regimen. The trial aims to establish a more effective approach to antibiotic use in this surgical context.
Why it matters
Potential benefit: If successful, this study could significantly reduce the rate of infections following orthognathic surgery, leading to better patient outcomes and reduced healthcare costs.
How similar studies have gone: Previous studies have shown that peri-operative antibiotics can reduce SSI rates in similar surgical contexts, indicating a potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients ASA 1 and 2 over the age of 16 undergoing orthognathic surgery will be offered participation in this study Exclusion Criteria: * Patients ASA 3 and higher, use of antibiotics in the preceding 2 weeks, presence of systemic, oral, or odontogenic infections, patients in a state of immunosuppression as a result of medications or systemic disease, patients with allergies to penicillins or cephalosporins, and patients who lack capacity for informed consent.
Where it's running
-
Victoria General Hospital
Halifax, Nova Scotia, Canada Recruiting
Study contacts
- Study coordinator: Abdul El-Rabbany, DMD, BSc
- Email: abdul.elrabbany@dal.ca
- Phone: 1-902-473-2070
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.