Clinical trial Recruiting at 1 site Interventional Ages 18 and up Women only

Using angiogenic factors to manage gestational hypertension

Official title: Use of Angiogenic Factors in the Conservative Management of Gestational Hypertension. Prospective, Randomised, Controlled Study.

Run by Saint Thomas Hospital, Panama · NCT06123377 · Data updated 2026-11-12

This study tests if certain biological markers can help doctors decide the best time to deliver babies for pregnant women with gestational hypertension to keep both mom and baby safe.

Quick facts

Study typeInterventional
Ages18 Years and up
SexWomen only
Enrollment150 (estimated)
SponsorSaint Thomas Hospital, Panama
Academic / other
Locations1 site (Panama City, Provincia de Panamá)
StatusRecruiting
StartedJune 1, 2024
Main results expectedAugust 15, 2026
Study endsSeptember 30, 2026
Registry record updatedAugust 26, 2025
Trial IDNCT06123377 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are pregnant women between 24 and 40 weeks of gestation diagnosed with gestational hypertension and having specific angiogenic factor levels.

Probably not a fit

Patients with multiple gestations, certain chronic conditions, or those with elevated angiogenic factor levels may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the role of angiogenic factors in the conservative management of gestational hypertension, a condition that poses risks to both mothers and their babies. By analyzing these factors, the study aims to differentiate between patients who may face complications and those who could benefit from prolonging their pregnancy. The approach focuses on pregnant women diagnosed with gestational hypertension, utilizing specific biomarkers to guide clinical decisions regarding the timing of delivery.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies for gestational hypertension, potentially reducing maternal and neonatal complications.

How similar studies have gone: While the use of angiogenic factors in pregnancy management is a developing area, this specific approach to gestational hypertension is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Pregnant women between 24 and 40 weeks of gestation.
* Diagnosis of Gestational Hypertension based on ACOG criteria
* index sFlt-1/PIGF equal or below 33

Exclusion Criteria:

* Multiple gestation
* Maternal vasculitis
* Previous cesarean section (3 or more)
* Neurological conditions
* Chronic renal disease
* Purpura
* Heart disease
* Index sFlt-1/PIGF of 34 or more

Where it's running

  • Hospital Santo Tomas
    Panama City, Provincia de Panamá, Panama
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.