Using an NMDA enhancer to treat schizophrenia without antipsychotics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the efficacy and safety of an NMDA enhancer (NMDAE) as a monotherapy for schizophrenia in patients who refuse or cannot tolerate antipsychotics. It is a 6-week randomized, double-blind trial where participants will receive either NMDAE or a placebo. Clinical performance and side effects will be measured biweekly, while cognitive functions will be assessed at the beginning and end of the treatment. The goal is to determine if NMDAE can effectively reduce symptoms and cognitive deficits associated with schizophrenia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have a DSM-5 (American Psychiatric Association) diagnosis of schizophrenia
* Refuse or are unable to tolerate antipsychotics due to poor response or adverse effects
* PANSS total score ≥ 60
* Free of antipsychotic drugs for at least 1 week
* Agree to participate in the study and provide informed consent

Exclusion Criteria:

* Current substance abuse or history of substance dependence in the past 3 months
* History of epilepsy, head trauma, stroke or other serious medical or neurological illness which may interfere with the study
* Use of depot antipsychotic in the past 3 months;
* Clinically significant laboratory screening tests
* Pregnancy or lactation
* Inability to follow protocol

Where it's running

• Department of Psychiatry, China Medical University Hospital
  Taichung, Taiwan Recruiting

Study contacts

• Study coordinator: Hsien-Yuan Lane, M.D., Ph.D
• Email: hylane@gmail.com
• Phone: 886 4 22052121

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.