Using Amino Acid PET/MRI to Diagnose Brain Tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of combining amino acid PET with MRI for diagnosing gliomas and brain metastases. It aims to improve the accuracy of tumor grading, assess true tumor volume, and differentiate viable tumor tissue from treatment-induced changes. The study will involve adult patients who are scheduled for tissue sampling or surgery for brain tumors, utilizing promising amino acid PET tracers to enhance diagnostic capabilities. The research seeks to compare different PET tracers and their diagnostic value in various brain neoplasms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inclusion criteria Glioma (LGG, HGG and recurrent HGG):

  * Planned treatment for WHO grade II-IV diffuse glioma
  * Adult patients (\>18 years)
  * Planned tissue sampling for histopathological diagnosis.
  * KPS \>60 (able to care for self)

Inclusion criteria Brain Metastasis:

* Indication of surgery or stereotactic radiosurgery for 1-4 brain metastases
* Planned surgery: Suspicion of brain metastasis or known diagnosis
* Stereotactic surgery: Known primary cancer
* Adult patients (\>18 years)
* Estimated survival at least 3 months after inclusion

Exclusion Criteria:

* Exclusion criteria (Glioma and Brain Metastasis):

  * Pacemakers or defibrillators not compatible with 3T MRI
  * No ability to obtain informed consent (e.g. due to severe dysphasia or cognitive deficits).
  * Pregnancy (pregnancy test for all women in fertile age when doubt about possible pregnancy exist)
  * Breastfeeding
  * Weight \> 120 kg

Where it's running

• St Olavs Hospital
  Trondheim, Norway Recruiting
• Haukeland universitetssykehus
  Bergen, Norway Not yet recruiting
• Universitetssykehus Nord Norge
  Tromsø, Norway Not yet recruiting

Study contacts

• Principal investigator: Live Eikenes, Phd — Norwegian University of Science and Technology
• Study coordinator: Live Eikenes, PhD
• Email: live.eikenes@ntnu.no
• Phone: 0047 99568081

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.