Using AI to improve detection and prediction of cerebral aneurysms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on the application of artificial intelligence models to enhance the segmentation, detection, and stability prediction of unruptured cerebral aneurysms. By utilizing advanced imaging techniques like magnetic resonance angiography (MRA) and computed tomography angiography (CTA), the study aims to improve diagnostic accuracy and identify high-risk aneurysms that are more likely to rupture. This approach seeks to alleviate the workload of diagnostic physicians while ensuring timely intervention for patients at risk of aneurysmal subarachnoid hemorrhage.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years;
2. Preliminary diagnosis or symptoms indicating the presence or potential presence of a cerebral aneurysm;
3. Undergoing a non-contrast head MRA or contrast-enhanced head/neck CTA;
4. The patient or their legal representative is able and willing to sign an informed consent form.

Exclusion Criteria:

1. Other intracranial vascular diseases: moyamoya disease, arteriovenous malformations, arteriovenous fistulas, arterial occlusions, and arterial dissections;
2. History of intracranial arterial interventions: stent placement, partial aneurysm coil treatment, etc.;
3. Severe allergy to contrast agents or absolute contraindications to iodine-based contrast agents;
4. Renal insufficiency with elevated serum creatinine (greater than twice the upper normal limit);
5. MRI contraindications: pacemakers, claustrophobia, etc.;
6. Diseases or conditions that affect the quality of CTA/MRA images;
7. Inability to complete the study due to psychiatric disorders, cognitive, or emotional disturbances.

Note: The CTA sub-study does not include exclusion criterion 5; the MRA sub-study does not include exclusion criteria 3 and 4.

Where it's running

• Shanghai Sixth People's Hospital, Shanghai, 200023
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Yueqi Zhu
• Email: zhuyueqi@hotmail.com
• Phone: +86-21-66301136

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.