Using advanced ultrasound to diagnose fetal nervous system anomalies
Role of New High Resolution Ultrasonographic Modalities for Diagnosis of Fetal Nervous System Anomalies
Woman's Health University Hospital, Egypt · NCT05778279
This study is testing if advanced ultrasound can help find problems with the fetal brain during mid-pregnancy scans in low-risk pregnancies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 20 Years to 28 Years |
| Sex | Female |
| Sponsor | Woman's Health University Hospital, Egypt (other) |
| Locations | 1 site (Assiut) |
| Trial ID | NCT05778279 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the use of high-resolution ultrasonography to evaluate the fetal central nervous system (CNS) during mid-trimester scans in low-risk pregnancies. It aims to assess the anatomical integrity of the fetal brain by examining specific planes of the brain, which can help identify potential malformations. The study is particularly important as CNS malformations are associated with significant morbidity and mortality, and early detection can guide parental counseling and management options. The evaluation includes detailed observation of structures such as the lateral ventricles and cerebellum, which are crucial for diagnosing anomalies.
Who should consider this trial
Good fit: Ideal candidates include pregnant individuals with suspected CNS or spinal malformations based on routine ultrasound or those with relevant family histories.
Not a fit: Patients with low-risk pregnancies are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance early detection of fetal CNS anomalies, leading to better management and outcomes for affected pregnancies.
How similar studies have performed: Other studies have shown success in using advanced ultrasound techniques for diagnosing fetal anomalies, indicating that this approach is promising.
Eligibility criteria
Show full inclusion / exclusion criteria
1. Inclusion criteria: 2. Suspicion of CNS or spinal malformation at routine screening ultrasound 3. Suspicion of CNS or spinal malformation at nuchal translucency scan 4. Family history of inheritable CNS spinal malformations 5. Previous pregnancy complicated by fetal brain or spinal malformation 6. Fetus with congenital heart disease 7. Monochorionic twins 8. Suspected congenital intrauterine infection Exposure to teratogens known to affect neurogenesis Exclusion Criteria: * Low risk pregnancy
Where this trial is running
Assiut
- Woman's Health University Hospital — Assiut, Egypt (RECRUITING)
Study contacts
- Principal investigator: Dina Darwish, MRCOG — Woman's Health University Hospital
- Study coordinator: Dina Darwish, MRCOG
- Email: dodydana12@gmail.com
- Phone: 0201001572723
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Ultrasound Therapy, Complications, Anomaly, Central Nervous System Diseases