Using advanced MRI to diagnose brain tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the safety and feasibility of hyperpolarized metabolic MRI for diagnosing infiltrating gliomas, a type of brain tumor. It will assess how accurately this advanced imaging technique can identify these tumors compared to standard MRI methods. The study will involve up to 5 patients at the University of Maryland, Baltimore, who have suspected infiltrating gliomas or a history of such tumors and are scheduled for surgery. The FDA has approved the use of hyperpolarized 13C-pyruvate in this investigation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Patients with a new brain lesion interpreted as suspected infiltrating gliomas including but not limited to (diffuse astrocytoma WHO grade 2; oligodendroglioma WHO grade 2 and 3; anaplastic astrocytoma WHO grade 3; astrocytoma WHO grade 4), OR, patients with prior history of infiltrating glioma scheduled for surgery for tumor biopsy or resection.

  * Ages 18-80, including male and female
  * Suitable to undergo contrast-enhanced MRI
  * Negative serum pregnancy test

Exclusion Criteria:

* Inability to undergo MRI scan
* Inability to receive IV contrast secondary to severe reaction or renal insufficiency.

Where it's running

• Rosy Njonkou Tchoquessi
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Dirk Mayer, Dr. rer. nat — University of Maryland, Baltimore
• Study coordinator: Rosy Njonkou Tchoquessi
• Email: rnjonkou@som.umaryland.edu
• Phone: 4107066445

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.