Using advanced MRI to assess chronic kidney disease
Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease
University Hospitals of Derby and Burton NHS Foundation Trust · NCT04238299
This study is testing if a special type of MRI can help doctors better understand and track the progression of chronic kidney disease in patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 450 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | University Hospitals of Derby and Burton NHS Foundation Trust (other) |
| Locations | 1 site (Derby, Derbyshire) |
| Trial ID | NCT04238299 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of multiparametric renal Magnetic Resonance Imaging (MRI) in assessing chronic kidney disease (CKD). It will involve three stages: initially testing MRI protocols on 45 CKD patients, followed by a larger cohort of 450 patients over two years to track CKD progression, and finally comparing MRI results with traditional renal biopsy in a subset of patients. The goal is to improve prognostic information and treatment options for CKD patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-75 with chronic kidney disease categories G1-4 and specific albuminuria levels.
Not a fit: Patients with conditions like autosomal dominant polycystic kidney disease or those who have had recent acute kidney injury may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate assessments and better management of chronic kidney disease.
How similar studies have performed: While the use of MRI in kidney assessment is emerging, this specific multiparametric approach is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Age 18-75 years * CKD category G3-4 or CKD category G1-2 with overt albuminuria (urine ACR\>30mg/mmol) * Capable of giving informed consent Exclusion Criteria * Autosomal dominant polycystic kidney disease (ADPKD) * Glomerulonephritis (GN) actively receiving immunosuppression, or within the preceding 90 days. * Multiple myeloma (MM) * Acute Kidney Injury (AKI) within the preceding 90 days * Solid organ transplant * Known single kidney * Contraindications to MRI (e.g. permanent pacemaker, metallic foreign bodies, claustrophobia etc.)
Where this trial is running
Derby, Derbyshire
- Royal Derby Hospital — Derby, Derbyshire, United Kingdom (RECRUITING)
Study contacts
- Study coordinator: Nicholas Selby
- Email: nicholas.selby@nottingham.ac.uk
- Phone: 01332 724665
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Chronic Kidney Diseases