Using advanced MRI techniques to improve diagnosis of focal epilepsy in children
Volumétrie Optimisée en Radiologie : intérêt en IRM Cérébrale pédiatrique Dans l'Exploration de l'épilepsie Focale
This study is testing new MRI techniques to see if they can help doctors find brain problems in children with suspected focal epilepsy that regular MRIs might miss.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 240 (estimated) |
| Ages | 1 Year to 18 Years |
| Sex | All |
| Sponsor | University Hospital, Tours Academic / other |
| Locations | 5 sites (Angers and 4 other locations) |
| Trial ID | NCT05100771 on ClinicalTrials.gov |
What this trial studies
This multicenter observational study aims to enhance the detection of brain lesions in children with suspected focal epilepsy by comparing traditional MRI methods with advanced quantitative volumetry and T1 relaxometry techniques. The study focuses on children aged 1-18 years who are being evaluated for epilepsy and require an MRI as part of their diagnostic work-up. By improving the sensitivity of brain imaging, the study seeks to identify subtle abnormalities that may not be visible with standard MRI, potentially leading to better management and treatment options for these patients.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 1-18 years who are being evaluated for focal onset epilepsy and require a brain MRI.
Not a fit: Patients who oppose data processing or have MRI results that are not interpretable will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy for children with focal epilepsy, allowing for more effective treatment strategies.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques for epilepsy diagnosis, suggesting that this approach may yield beneficial results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged 1-18 years * Referred or followed by a pediatrician for epilepsy with focal onset * Requiring brain MRI as part of the work-up Exclusion Criteria: * Opposition of the child and/or parent to data processing * MRI not interpretable * Clinical and epileptic data not available or not specifying focus
Where this trial is running
Angers and 4 other locations
- CHU Angers — Angers, France (Not_yet_recruiting)
- CHU Grenoble — Grenoble, France (Not_yet_recruiting)
- CHU Montpellier — Montpellier, France (Not_yet_recruiting)
- CHU Rennes — Rennes, France (Not_yet_recruiting)
- Hôpital Clocheville — Tours, France (Recruiting)
Study contacts
- Principal investigator: Baptiste Morel — CHU Tours
- Study coordinator: Baptiste Morel
- Email: baptiste.morel@univ-tours.fr
- Phone: 02 47 47 47 58
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.