Using advanced MRI and AI to find early signs of cancer in children with Neurofibromatosis Type 1

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial involves a single-arm intervention using whole-body Magnetic Resonance Imaging (MRI) combined with artificial intelligence to assess the feasibility and predictive value of detecting pre-malignant lesions in pediatric patients diagnosed with Neurofibromatosis Type 1 (NF-1). The study will evaluate scan-rescan reliability and changes in MRI scans over a 12-month period among 15 participants at Cedars-Sinai Medical Center. The goal is to improve early detection of potential malignancies in this high-risk population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Between the ages of 5 and \<18 years at the start of study. If subject will turn 18 during the study, they will be allowed to enroll.
* Clinically or molecularly confirmed diagnosis of NF-1. Subjects with mosaic/segmental NF-1 also qualify for the study.

Exclusion Criteria:

* Requiring sedation for imaging.
* Implants and/or Devices: Mechanical, magnetic or electrical activated implants; Ferromagnetic implants and foreign bodies
* Claustrophobia, problems being in enclosed spaces, or inability to lie facing upwards.
* Allergy to animal dander or animal-instigated asthma.

Where it's running

• Cedars Sinai Medical Center
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Nicole Baca, MD — Cedars-Sinai Medical Center
• Study coordinator: Clinical Trial Recruitment Navigator
• Email: GroupCancerTrialInformation@cshs.org
• Phone: 3104232133

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.