Using advanced imaging to study biofilm in endotracheal tubes for critically ill patients
Dynamic Full-field Optical Coherence Tomography for Endotracheal Tube Biofilm Characterization in Critically Ill Patients
This study is trying to understand the germs that build up in breathing tubes used for critically ill patients to see if it can help prevent pneumonia caused by ventilators.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 2 sites (Chalon-sur-Saône and 1 other locations) |
| Trial ID | NCT06379139 on ClinicalTrials.gov |
What this trial studies
This observational study aims to characterize the biofilm present in endotracheal tubes used in critically ill patients, which is linked to ventilator-associated pneumonia (VAP). By employing Dynamic Full-Field Optical Coherence Tomography, the study seeks to provide a detailed analysis of the microbiological structures within the biofilm. The findings could lead to improved strategies for managing and preventing VAP in intensive care settings. The study includes patients who have been mechanically ventilated for at least two days and have provided informed consent.
Who should consider this trial
Good fit: Ideal candidates are critically ill patients over 18 years old who have been on mechanical ventilation for at least two days.
Not a fit: Patients who are unable to provide informed consent or whose endotracheal tube samples cannot be collected will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prevention and management strategies for ventilator-associated pneumonia in critically ill patients.
How similar studies have performed: While the approach of using advanced imaging techniques for biofilm characterization is relatively novel, previous studies have indicated the importance of targeting biofilm in preventing VAP.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient or relative informed of the study and having declared their nonobjection * Patient over 18 years of age * Patient exposed to mechanical ventilation for at least two calendar days Exclusion Criteria: * Patient unable to declare their nonobjection * Patient whose endotracheal tube collection is impossible * Patient whose endotracheal tube is collected following self-extubation (sample contamination)
Where this trial is running
Chalon-sur-Saône and 1 other locations
- CH William Morey — Chalon-sur-Saône, France (Recruiting)
- CHU Dijon Bourgogne — Dijon, France (Recruiting)
Study contacts
- Principal investigator: Thomas MALDINEY — CH William Morey
- Study coordinator: Thomas MALDINEY
- Email: thomas.maldiney@ch-chalon71.fr
- Phone: 385910474
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.