Using advanced eye imaging to study memory impairment
Official title: OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT04389437 · Data updated 2026-11-12
This study is trying to see if new eye imaging techniques can help find changes in the retina that might be linked to memory problems like Alzheimer's and other types of dementia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 450 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | June 26, 2020 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | October 30, 2026 |
| Trial ID | NCT04389437 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals presenting with memory complaints or those accompanying such patients.
✕Probably not a fit
Patients with significant retinal pathology or severe cognitive impairment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the relationship between retinal abnormalities and neurocognitive disorders (NCD) such as Alzheimer's disease and other forms of dementia. It employs two innovative ophthalmological imaging techniques, Optical Coherence Tomography Angiography (OCT-A) and Adaptive Optics (AO), to non-invasively analyze the morphology of small retinal vessels and the overall architecture of the retina. By comparing these parameters, the study aims to identify specific retinal anomalies associated with various NCDs, potentially serving as in vivo markers of the underlying pathophysiological processes. This pilot study is the first of its kind to explore these techniques in the context of memory impairment.
Why it matters
Potential benefit: If successful, this study could lead to new diagnostic markers for early detection of neurocognitive disorders.
How similar studies have gone: While this approach is novel and has not been tested in this specific context, similar studies have shown promise in linking retinal health to neurodegenerative conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint Exclusion Criteria: * pregnant or lactating women * history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis) * history of retinal pathology * ametropia greater in absolute value than 3 diopters on the sphere, or/and 1.5 diopters on the cylinder. * history of taking ethambutol for more than 2 months * history of takingsynthetic antimalarial for more than 2 years * Mini Mental State Score (MMS) and / or Montreal Cognitive Assessment (MoCA) \<10 for patients and 26 for accompanying persons * MRI contraindication (for patients only)
Where it's running
-
Hôpital Fondation A. de Rothschild
Paris, France Recruiting
Study contacts
- Principal investigator: Antoine MOULIGNIER, MD — Fondation A. de Rothschild
- Study coordinator: Amélie YACHITZ, MD
- Email: ayavchitz@for.paris
- Phone: (0)148036454
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.