Using advanced eye imaging to study memory impairment
OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
This study is trying to see if new eye imaging techniques can help find changes in the retina that might be linked to memory problems like Alzheimer's and other types of dementia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 450 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Trial ID | NCT04389437 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between retinal abnormalities and neurocognitive disorders (NCD) such as Alzheimer's disease and other forms of dementia. It employs two innovative ophthalmological imaging techniques, Optical Coherence Tomography Angiography (OCT-A) and Adaptive Optics (AO), to non-invasively analyze the morphology of small retinal vessels and the overall architecture of the retina. By comparing these parameters, the study aims to identify specific retinal anomalies associated with various NCDs, potentially serving as in vivo markers of the underlying pathophysiological processes. This pilot study is the first of its kind to explore these techniques in the context of memory impairment.
Who should consider this trial
Good fit: Ideal candidates include individuals presenting with memory complaints or those accompanying such patients.
Not a fit: Patients with significant retinal pathology or severe cognitive impairment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new diagnostic markers for early detection of neurocognitive disorders.
How similar studies have performed: While this approach is novel and has not been tested in this specific context, similar studies have shown promise in linking retinal health to neurodegenerative conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint Exclusion Criteria: * pregnant or lactating women * history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis) * history of retinal pathology * ametropia greater in absolute value than 3 diopters on the sphere, or/and 1.5 diopters on the cylinder. * history of taking ethambutol for more than 2 months * history of takingsynthetic antimalarial for more than 2 years * Mini Mental State Score (MMS) and / or Montreal Cognitive Assessment (MoCA) \<10 for patients and 26 for accompanying persons * MRI contraindication (for patients only)
Where this trial is running
Paris
- Hôpital Fondation A. de Rothschild — Paris, France (Recruiting)
Study contacts
- Principal investigator: Antoine MOULIGNIER, MD — Fondation A. de Rothschild
- Study coordinator: Amélie YACHITZ, MD
- Email: ayavchitz@for.paris
- Phone: (0)148036454
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.