Using a special solution to prevent infections in dialysis catheters
Official title: Evaluation of the Efficacy of an inTerdialytic "Ethanol 40% v/v - enoxapaRin 1000 U/mL" Lock solutioN to Prevent Tunnelled Catheter Infections in Chronic Hemodialysis Patients: a mulTi-centre, Randomized, Single Blind, Parallel Group studY (ETERNITY)
Run by University Hospital, Clermont-Ferrand · NCT03083184 · Data updated 2026-11-12
This study is testing a new solution made of ethanol and heparin to see if it can help prevent infections in dialysis catheters for people on chronic hemodialysis.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 1 site (Clermont-Ferrand) |
| Status | Recruiting |
| Started | February 9, 2018 |
| Main results expected | December 2026 |
| Study ends | December 2027 |
| Registry record updated | December 8, 2023 |
| Trial ID | NCT03083184 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are chronic hemodialysis patients with end-stage renal disease who have a functional tunnelled catheter.
✕Probably not a fit
Patients who do not have a tunnelled catheter or are not undergoing chronic hemodialysis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of a combined solution of ethanol and low molecular weight heparin in preventing infections related to tunnelled dialysis catheters in chronic hemodialysis patients. The research focuses on reducing catheter-related infections, which are common complications in this patient population and can lead to increased healthcare costs and mortality. By targeting biofilm formation, the study aims to provide a safer alternative to traditional antibiotic lock solutions, which carry risks of resistance. Participants will receive the new lock solution during their hemodialysis sessions to assess its efficacy over time.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of catheter-related infections in hemodialysis patients, improving their overall health outcomes.
How similar studies have gone: Previous studies have shown promise in using antiseptic solutions to prevent catheter infections, but this specific combination of ethanol and low molecular weight heparin is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * end-stage renal disease * chronic hemodialysis/hemodiafiltration at least three times a week * functional TC inserted for at least two weeks * Social security cover * Written informed consent Exclusion Criteria: \-
Where it's running
-
CHU Clermont-Ferrand
Clermont-Ferrand, France Recruiting
Study contacts
- Principal investigator: Julien ANIORT — University Hospital, Clermont-Ferrand
- Study coordinator: Patrick LACARIN
- Email: placarin@chu-clermontferrand.fr
- Phone: 04 73 75 10 81
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Ovarian drilling via vNOTES laparoscopy for PCOS patients
This study tests whether drilling the ovaries using vNOTES laparoscopy can help women with PCOS who did not respond to first-line medicines.
-
Work and leisure physical activity short questionnaire validation
This study tests a shorter questionnaire to see if it accurately measures work and leisure activity and sedentary time by comparing it with a well-established reference questionnaire.
-
AI-assisted embryo selection on day 5 in IVF for infertility
This trial tests whether an AI-based embryo selection tool can help pick the best embryo for transfer on day 5 in IVF/ICSI to improve pregnancy chances for people with infertility.
-
Endothelial Function in Healthy Women Over 50 See How Your Blood Vessels Work
This study tests whether flow-mediated dilation (FMD) measurements in healthy women aged 50 and older can establish reference values.
-
Preventive habits of physicians (PREVMED) so doctors’ cancer screening and lifestyle advice patterns
This study tests how doctors and medical residents practice prevention with patients, and what personal or work factors might influence those practices.
-
Impact of Phosphate Supplementation on FGF23 Levels in Hypophosphatemia Patients
This study tests whether giving phosphate affects FGF23 levels in adults with low phosphate who need supplementation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.