Using a simple breathing test to detect and monitor BOS after stem cell transplant
Official title: Forced Oscillatory Technique for the Diagnosis, Monitoring, and Assessment of Treatment Response in Bronchiolitis Obliterans Syndrome Following Allogeneic Bone Marrow Transplantation
Run by Hadassah Medical Organization · NCT07730931 · Data updated 2026-11-12
This study tests whether the Forced Oscillation Technique (FOT) can help diagnose and track bronchiolitis obliterans syndrome in people who have had an allogeneic hematopoietic stem cell transplant.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Months and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Hadassah Medical Organization Academic / other |
| Locations | 1 site (Jerusalem) |
| Status | Recruiting |
| Started | August 19, 2021 |
| Main results expected | December 30, 2028 |
| Study ends | December 30, 2030 |
| Registry record updated | July 28, 2026 |
| Trial ID | NCT07730931 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 6 months or older undergoing allogeneic HSCT and referred for pulmonary function testing at Hadassah Ein Kerem Institute of Pulmonary Medicine.
✕Probably not a fit
Patients unable to perform FOT or who do not develop BOS or small airway disease may not experience a direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective study at Hadassah Medical Organization will compare Forced Oscillation Technique measurements with standard lung function tests in patients aged 6 months and older undergoing allogeneic HSCT. Participants will undergo FOT alongside spirometry, static lung volumes, and DLCO, with data collected on clinical and transplant characteristics and imaging. They will be followed for up to three years to evaluate FOT’s utility in diagnosis, monitoring, and treatment response for BOS and small airway disease after HSCT.
Why it matters
Potential benefit: If successful, FOT could provide a less invasive or more sensitive method to detect BOS early and monitor disease progression or treatment response.
How similar studies have gone: Prior studies in BOS and post-transplant lung disease suggest that complementary tests like FOT may add value, but this approach is exploratory in this setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. All patients age 6 months and above, undergoing allogeneic HSCT, referred for pulmonary function test evaluation at the Hadassah Ein Kerem Institute of Pulmonary Medicine . 2. Ability to provide informed consent for performing FOT and database enrollment by patient or legal guardians. Exclusion Criteria: 1\. Inability or unwillingness to perform FOT
Where it's running
-
Hadassah MO, Jerusalem, 9574869, Jerusalem,
Jerusalem, Israel Recruiting
Study contacts
- Study coordinator: Rottem Kuint, MD
- Email: KUINT@hadassah.org.il
- Phone: +972532207609
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Long-term lung monitoring after allogeneic hematopoietic stem cell transplant for bronchiolitis obliterans syndrome
We will follow about 600 adults having their first allogeneic stem cell transplant to see how often and how bronchiolitis obliterans syndrome (pulmonary GvHD) appears and changes over time.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.