Long-term lung monitoring after allogeneic hematopoietic stem cell transplant for bronchiolitis obliterans syndrome
Official title: Longitudinal Pulmonary Chronic Graft-versus-host-disease (GvHD) Assessment in Hematopoietic Stem Cell Transplantation (HSCT) Patients
Run by National Taiwan University Hospital · NCT07297303 · Data updated 2026-11-12
We will follow about 600 adults having their first allogeneic stem cell transplant to see how often and how bronchiolitis obliterans syndrome (pulmonary GvHD) appears and changes over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | September 30, 2025 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | December 22, 2025 |
| Trial ID | NCT07297303 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 scheduled for their first allogeneic HSCT at National Taiwan University Hospital who can ambulate at least 20 meters and cooperate with serial pulmonary testing are ideal candidates.
✕Probably not a fit
Patients with respiratory failure, need for continuous (all-day) oxygen, recent acute coronary syndrome, severe lower-limb arthropathy, inability to walk 20 meters, poor cooperation, or prior lung transplantation are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational cohort will enroll roughly 600 adult Taiwanese recipients of first-time allogeneic hematopoietic stem cell transplantation and perform scheduled pulmonary function testing (including impulse oscillometry), imaging, cardiopulmonary exercise testing, and biomarker sampling to track pulmonary graft-versus-host disease (BOS). Participants will be followed serially after transplant to document timing of onset, symptom development, lung function decline, and radiographic changes and to relate these findings to clinical risk factors. The protocol excludes patients with prior lung transplant, active respiratory failure, hemodynamic instability, or inability to perform walking/exercise tests. Collected data aim to fill local gaps in epidemiology, improve understanding of early or subclinical disease, and inform follow-up and management strategies for HSCT recipients.
Why it matters
Potential benefit: If successful, the study could identify earlier signs, risk factors, and biomarkers that help detect or monitor pulmonary GvHD sooner and guide follow-up care for transplant recipients.
How similar studies have gone: Prior cohort studies have described the timing, risk factors, and lung-function decline in BOS after HSCT, but effective treatments remain limited and local Taiwanese data have been sparse.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age\>18 2. Will Receive first time Allo-HSCT patients Exclusion Criteria: 1. Respiratory failure 2. Hemodynamic unstable 3. Pneumothorax or bronchial fistula 4. Acute coronary syndrome in recent 1 month 5. The patient couldn't walk longer than 20 m 6. Severe lower-limb arthropathy 7. The patient couldn't cooperate well 8. Need all-day oxygen supplement 9. The patient received lung transplantation before
Where it's running
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National Taiwan University Hospital
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Ting-Yu Liao
- Email: tingyufish0129@gmail.com
- Phone: +886 2312-3456
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using a simple breathing test to detect and monitor BOS after stem cell transplant
This study tests whether the Forced Oscillation Technique (FOT) can help diagnose and track bronchiolitis obliterans syndrome in people who have had an allogeneic hematopoietic stem cell transplant.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.