Using a new imaging technique for low grade gliomas after surgery
Non-invasive In-vivo Characterisation of Postoperative Low Grade Gliomas Using Field Cycling Imaging (FCI)
This study is testing a new imaging technique to see if it can better identify different types of brain tumors in patients after surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | NHS Grampian Government |
| Locations | 1 site (Aberdeen) |
| Trial ID | NCT06294418 on ClinicalTrials.gov |
What this trial studies
This pilot study aims to evaluate the effectiveness of Field Cycling Imaging (FCI) in differentiating subtypes of postoperative low grade gliomas. Participants will undergo one FCI scan to assess the relaxometry characteristics of their brain lesions. FCI is a novel imaging technology that combines high and low magnetic fields to provide detailed quantitative data on tissue molecular dynamics, potentially overcoming limitations of standard MRI. The study is being conducted at the University of Aberdeen and involves ten patients.
Who should consider this trial
Good fit: Ideal candidates include patients aged 16 and above who have undergone surgery for low grade glioma and can provide informed consent.
Not a fit: Patients with MRI-incompatible conditions, severe mobility restrictions, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the ability to accurately classify low grade gliomas, leading to better tailored treatment strategies for patients.
How similar studies have performed: While FCI is a novel approach, similar advanced imaging techniques have shown promise in differentiating tumor types in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with post operative low-grade glioma. * Capacity to give informed consent. * Capacity to co-operate with the scanning procedures and duration. * Age 16 and above. * Participants who can pass through a 50 cm-diameter circular hoop to ensure they will be able to fit inside the scanner. * Participants who meet the safety criteria for undergoing an MRI scan. * Participants must be mobile enough to be positioned onto the FCI scanner couch. Exclusion Criteria: * MRI-incompatible conditions, as detected in the MRI safety screening form. * Restrictions to mobility that would prevent the correct positioning in the scanner by trained research radiographer (e.g., severe kyphosis). * Participants who are unable to give fully informed consent. * Women who are pregnant. * Participants who are unable to understand or communicate in English. * Patients who suffer from claustrophobia.
Where this trial is running
Aberdeen
- Aberdeen Royal Infirmary — Aberdeen, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Celia G Alvarez Campano, Dr
- Email: celia.alvarezcampano@abdn.ac.uk
- Phone: +441224437828
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.