Using a mobile app to improve medication adherence for atrial fibrillation patients

The Effect of App. for Medication-check and Video-call Guided Education on APIXABAN Adherence in Patients of Atrial Fibrillation With Cardiac Disease: Randomised Control Pilot Study(APIXABAN Study)

NA · Seoul National University Bundang Hospital · NCT06903845

This study is testing if a medication reminder app, along with video education, can help people with atrial fibrillation take their apixaban medication more regularly.

Quick facts

PhaseNA
Study typeInterventional
Enrollment40 (estimated)
Ages19 Years and up
SexAll
SponsorSeoul National University Bundang Hospital (other)
Locations1 site (Seongnam, Gyeonggido)
Trial IDNCT06903845 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effectiveness of a medication reminder app combined with bi-weekly video education in improving adherence to apixaban among patients with atrial fibrillation and comorbidities. Participants will be randomly assigned to either a treatment group, which receives both the app and video calls, or a control group that only uses the app. The study aims to measure changes in medication adherence after eight weeks of intervention. By leveraging digital health tools, the trial seeks to enhance patient engagement and medication compliance.

Who should consider this trial

Good fit: Ideal candidates are adults aged 19 or older with atrial fibrillation and at least one cardiovascular or metabolic comorbidity who are currently taking or planning to take apixaban.

Not a fit: Patients with severe renal impairment, significant mitral valve issues, or a history of substance abuse may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly improve medication adherence in patients with atrial fibrillation, leading to better health outcomes.

How similar studies have performed: While the use of mobile applications for medication adherence is gaining traction, this specific combination of app and video education is relatively novel and has not been extensively tested in similar studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Participants must meet all of the following criteria:

Adults aged 19 years or older with a diagnosis of atrial fibrillation (AF)

Presence of at least one of the following cardiovascular or metabolic comorbidities:

A. Heart failure

B. Hypertension

C. Coronary artery disease

D. Peripheral arterial disease

E. Diabetes mellitus

F. Stroke

G. Other cardiac diseases requiring treatment

Currently taking or planning to initiate oral anticoagulation therapy with apixaban

Able to use a smartphone with an Android operating system

Voluntarily provided written informed consent to participate in the clinical trial after being adequately informed of its purpose, procedures, and potential risks

2\. Exclusion Criteria

Participants will be excluded if any of the following conditions apply:

Creatinine clearance (CCr) \< 15 mL/min

Presence of moderate to severe mitral stenosis

History of mitral valve repair or replacement

Clinically significant history of alcohol or substance abuse

Deemed by the investigator to be legally or psychologically unsuitable for participation in the clinical trial

Participation in another clinical trial involving investigational drugs within 4 weeks prior to screening

Declines or is unwilling to provide informed consent for participation in this study

Where this trial is running

Seongnam, Gyeonggido

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Atrial Fibrillation, atrial fibrillation, mobile application, digital health, medication adherence

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.