Uric acid clearance with routine hemodialysis in adults on maintenance dialysis
Official title: Assessment of the Efficacy of Hemodialysis on Uric Acid Clearance at End Stage Kidney Disease in Sohag University Hospital
Run by Sohag University · NCT07144332 · Data updated 2026-11-12
This project tests whether routine hemodialysis alone removes enough uric acid in adults with end-stage kidney disease who dialyze two or three times per week.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag) |
| Status | Recruiting |
| Started | July 13, 2025 |
| Main results expected | December 29, 2025 |
| Study ends | February 1, 2026 |
| Registry record updated | August 27, 2025 |
| Trial ID | NCT07144332 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older who have been on maintenance hemodialysis for at least three consecutive months, receive two to three sessions weekly of at least four hours, and are not taking uric-acid–lowering therapy.
✕Probably not a fit
Patients already on uric-acid–lowering medications, those on dialysis for under three months, those receiving emergency or shorter-than-four-hour sessions, and people on non-hemodialysis renal replacement therapies are unlikely to benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective cross-sectional study will enroll 100 consenting adults on maintenance hemodialysis at Sohag University Hospital over six months. Investigators will collect demographic and dialysis-related data and measure serum uric acid immediately before and after routine dialysis sessions to calculate uric acid clearance. Clearance between 65% and 80% is defined as low efficacy and above 80% as good efficacy. Patients on uric-acid–lowering drugs, those dialyzing less than four hours, who have been on dialysis for under three months, or who receive emergency dialysis sessions are excluded.
Why it matters
Potential benefit: If routine hemodialysis alone clears uric acid effectively, some patients may be able to avoid additional uric-acid–lowering medications.
How similar studies have gone: Previous studies show hemodialysis reduces serum uric acid but reported clearance rates vary widely, so reliance on dialysis alone to control hyperuricemia remains uncertain.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * We included all consenting adults aged 18 or older, on maintenance hemodialysis for at least 3 consecutive months receiving 2 to 3 sessions weekly Exclusion Criteria: 1. Patients aged \< 18 years old . 2. Patients on recent hemodialysis less than 3 months. 3. We excluded patients who were on Uric acid lowering therapy (UALT). 4. Patients received less than 4 hours of hemodialysis and those who had emergency dialysis.
Where it's running
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Sohag university faculty of medicine
Sohag, Egypt Recruiting
Study contacts
- Study coordinator: Reham Hussien, master
- Email: rehamhussien1937@yahoo.com
- Phone: 00201092162739
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.