Uric acid clearance with routine hemodialysis in adults on maintenance dialysis

Assessment of the Efficacy of Hemodialysis on Uric Acid Clearance at End Stage Kidney Disease in Sohag University Hospital

This project tests whether routine hemodialysis alone removes enough uric acid in adults with end-stage kidney disease who dialyze two or three times per week.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Sohag University (other)
• Locations: 1 site (Sohag)
• Trial ID: NCT07144332 on ClinicalTrials.gov

What this trial studies

This prospective cross-sectional study will enroll 100 consenting adults on maintenance hemodialysis at Sohag University Hospital over six months. Investigators will collect demographic and dialysis-related data and measure serum uric acid immediately before and after routine dialysis sessions to calculate uric acid clearance. Clearance between 65% and 80% is defined as low efficacy and above 80% as good efficacy. Patients on uric-acid–lowering drugs, those dialyzing less than four hours, who have been on dialysis for under three months, or who receive emergency dialysis sessions are excluded.

Who should consider this trial

Good fit: Adults aged 18 or older who have been on maintenance hemodialysis for at least three consecutive months, receive two to three sessions weekly of at least four hours, and are not taking uric-acid–lowering therapy.

Not a fit: Patients already on uric-acid–lowering medications, those on dialysis for under three months, those receiving emergency or shorter-than-four-hour sessions, and people on non-hemodialysis renal replacement therapies are unlikely to benefit from the findings.

Why it matters

Potential benefit: If routine hemodialysis alone clears uric acid effectively, some patients may be able to avoid additional uric-acid–lowering medications.

How similar studies have performed: Previous studies show hemodialysis reduces serum uric acid but reported clearance rates vary widely, so reliance on dialysis alone to control hyperuricemia remains uncertain.

Eligibility criteria

Inclusion Criteria:

* We included all consenting adults aged 18 or older, on maintenance hemodialysis for at least 3 consecutive months receiving 2 to 3 sessions weekly

Exclusion Criteria:

1. Patients aged \< 18 years old .
2. Patients on recent hemodialysis less than 3 months.
3. We excluded patients who were on Uric acid lowering therapy (UALT).
4. Patients received less than 4 hours of hemodialysis and those who had emergency dialysis.

Where this trial is running

Sohag

• Sohag university faculty of medicine — Sohag, Egypt (RECRUITING)

Study contacts

• Study coordinator: Reham Hussien, master

Conditions: Hemodialysis, Hyperuricemia, chronic kidney disease