Understanding why some patients struggle to stop mechanical ventilation
Changes in Respiratory Mechanics in Patients With Failed Ventilator Withdrawal
The First Affiliated Hospital of Guangzhou Medical University · NCT06424314
This study looks at why some people with COPD have trouble stopping mechanical ventilation after being on it for a while, by testing their breathing and comparing the results of those who succeed and those who don’t.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | The First Affiliated Hospital of Guangzhou Medical University (other) |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06424314 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the physiological mechanisms behind weaning failure in patients with chronic obstructive pulmonary disease (COPD) who have been on invasive mechanical ventilation for at least 48 hours. Participants will undergo a spontaneous breathing test (SBT), and their demographic and physiological data will be collected prior to the test. Based on the SBT outcomes, patients will be categorized into successful and failed withdrawal groups, allowing for a comparison of physiological changes during the SBT between these groups.
Who should consider this trial
Good fit: Ideal candidates for this study are adults with COPD who have been on invasive mechanical ventilation for a minimum of 48 hours.
Not a fit: Patients with neuromuscular diseases, postoperative conditions, or traumatic brain injuries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for weaning patients off mechanical ventilation, enhancing recovery and outcomes for individuals with COPD.
How similar studies have performed: While this study explores a specific aspect of weaning failure, similar observational studies have shown promise in understanding mechanical ventilation outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Invasive mechanical ventilation for at least 48 hours Exclusion Criteria: * neuromuscular disease；Postoperative patients or patients with traumatic brain injury
Where this trial is running
Guangzhou, Guangdong
- The First Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China (RECRUITING)
Study contacts
- Study coordinator: Lili Guan, MD & PhD
- Email: dr_nickguan@163.com
- Phone: 020-81566675
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Weaning Failure, Central Respiratory Depression, Diaphragm Injury, Phrenic Nerve Disorder