Understanding why diabetic wounds heal poorly
Official title: Mechanisms Underlying Impaired Wound Healing
Run by University of Pittsburgh · NCT00777712 · Data updated 2026-11-12
This study is trying to understand why wounds heal poorly in people with diabetes by looking at the differences in certain cells from their wounds compared to those from people without diabetes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years to 80 Years |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 2 sites (Pittsburgh, Pennsylvania and 1 other locations) |
| Status | Recruiting |
| Started | September 1, 2008 |
| Main results expected | December 31, 2029 |
| Study ends | December 31, 2030 |
| Registry record updated | June 5, 2026 |
| Trial ID | NCT00777712 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 21-80 with chronic wounds lasting more than four weeks, both diabetic and non-diabetic.
✕Probably not a fit
Patients who are pregnant, immunocompromised, or unable to provide consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to investigate the inflammatory cells derived from chronic wounds in diabetic and non-diabetic individuals to uncover the mechanisms behind impaired wound healing in diabetes. It will compare the biology of these wound-derived cells with normal peripheral blood cells to identify differences in their function. The study will involve blood draws from participants with chronic wounds lasting more than four weeks, focusing on both diabetic and non-diabetic patients. The ultimate goal is to elucidate the molecular pathways that contribute to the dysregulated inflammation seen in diabetic wound healing.
Why it matters
Potential benefit: If successful, this study could lead to improved treatments for chronic wounds in diabetic patients.
How similar studies have gone: Other studies have explored similar mechanisms of wound healing in diabetes, but this specific approach may provide novel insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 21-80 * Chronic Wound (present \>4 weeks) * Diabetic \& Non-diabetic * Adult surgical wounds Exclusion Criteria: * Inability to consent * Pregnant women * Therapeutically immunocompromised * Individuals defined in 45 CFR 46 Subparts B,C, and D, nor from any other population considered vulnerable 2.9
Where it's running
-
UPMC Montefiore
Pittsburgh, Pennsylvania, United States Recruiting -
UPMC Presbyterian
Pittsburgh, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Sashwati Roy, Ph.D. — University of Pittsburgh
- Study coordinator: Piya Das Ghatak, PhD, MS
- Email: pid12@pitt.edu
- Phone: 412-648-8297
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study tests if using special ultrasound images can help track how well chronic ulcers, like diabetic foot ulcers, are healing and how treatment affects blood flow around the wounds.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.