Understanding tumor evolution in early-stage non-small cell lung cancer
Official title: A Multiomics Study of Tumor Evolution Characteristics and Prognostic Model in Early-stage Non-small Cell Lung Cancer
Run by Peking University People's Hospital · NCT05352035 · Data updated 2026-11-12
This study is trying to understand how early-stage non-small cell lung cancer changes over time by looking at tumor samples and DNA to help improve treatment and monitoring for patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Peking University People's Hospital Academic / other |
| Locations | 1 site (Beijing) |
| Status | Recruiting |
| Started | April 20, 2022 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | April 30, 2025 |
| Trial ID | NCT05352035 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with early-stage NSCLC who have undergone radical surgical resection.
✕Probably not a fit
Patients with a history of other malignant tumors or evidence of distant metastasis prior to surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the evolutionary mechanisms of early-stage non-small cell lung cancer (NSCLC) through multiomics analysis. By analyzing tumor tissue and circulating tumor DNA, the study seeks to establish a prognostic model and a recurrence monitoring system. The findings could enhance the management of lung cancer patients and improve their overall prognosis. The study will utilize available clinical-pathologic data, imaging data, and follow-up information to support its objectives.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic models and monitoring systems for early-stage NSCLC patients.
How similar studies have gone: While multiomics approaches are gaining traction, this specific study's focus on early-stage NSCLC and its prognostic implications is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years old; 2. Early-stage NSCLC patients underwent radical surgical resection; 3. Sufficient tumor tissue and blood sample for study use; 4. Available clinical-pathologic data, imaging data and follow-up date; 5. Written informed consent. Exclusion Criteria: 1. History of other malignant tumors; 2. Evidence of distant metastasis before surgery; 3. Insufficient tumor tissue or blood sample for study use; 4. Clinical-pathologic data, imaging data or follow-up date is not available; 5. Other judgments by the Investigator that the patient should not participate in the study.
Where it's running
-
Peking University People's Hospital
Beijing, China Recruiting
Study contacts
- Study coordinator: Kezhong Chen, M.D.
- Email: chenkezhong@pkuph.edu.cn
- Phone: +86-010-88326657
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Patient-specific MRD liquid biopsy for resected NSCLC
This study tests a personalized MRD blood and bronchial washing test after surgery to see if it can signal recurrence earlier in people with resected NSCLC.
-
Osimertinib Plus SRS/SRT for EGFR-Mutant NSCLC with Symptomatic Brain Metastases
This study tests whether adding targeted brain radiotherapy to osimertinib helps control brain metastases in adults with EGFR-mutant NSCLC and neurological symptoms.
-
Dato-DXd in solid tumors (Urothelial Cancer and KRAS-mutant NSCLC) in two sub-studies
This study tests Datopotamab Deruxtecan (Dato-DXd) alone or with other cancer drugs in people with urothelial cancer or KRAS-mutant non-small cell lung cancer.
-
SI-B036 safety test in advanced and metastatic solid tumors
This early-phase study checks whether SI-B036 is safe and tolerable in adults with advanced or metastatic solid cancers who have had prior therapy.
-
Postoperative EGFR-TKI Therapy for EGFR-mutant NSCLC Following Surgery
This registry tests whether giving an EGFR-TKI after surgery helps adults with EGFR-mutant, high-risk early-stage NSCLC.
-
HS-20093 with Adebrelimab vs HS-20093 alone in advanced non-squamous NSCLC
This study tests whether adding adebrelimab to HS-20093 helps patients with advanced non-squamous NSCLC who have already had treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.