Understanding tooth erosion in patients with esophagogastric cancer
Pilot Study of Dental Erosion as a Non-invasive Biomarker of Esophagogastric Cancer
This study is trying to find out what causes tooth enamel loss in people with esophagogastric cancer by comparing them to healthy volunteers.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Memorial Sloan Kettering Cancer Center Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT05612048 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the factors contributing to tooth enamel loss in individuals diagnosed with esophagogastric cancer and other related cancers. Participants will undergo surveys and have their teeth photographed using an intra-oral camera to assess enamel status. The study will also include healthy volunteers for comparison. By analyzing the data collected, researchers hope to identify the prevalence and causes of tooth erosion in this patient population.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with a history of esophagogastric cancer, colorectal cancer, pancreatic cancer, breast cancer, head and neck cancer, non-small cell lung cancer, or healthy volunteers.
Not a fit: Patients without evaluable molars or significant dental work that affects enamel assessment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better dental care strategies for patients with esophagogastric cancer, potentially improving their quality of life.
How similar studies have performed: While this specific approach is novel, related studies have explored dental health in cancer patients, indicating a growing interest in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject is willing and able to provide written informed consent. * Patients with a history of esophagogastric, HNSCC, PDAC, CRC, or NSCLC or healthy controls * Patients must be able to fully comprehend and complete the survey and be willing to have pictures taken of their teeth with a camera or intra-oral camera. * Patients must be able to understand English language or have access to adequate translation services. * Age ≥ 18 years old. Exclusion Criteria: * Subjects without evaluable molars or with significant molar dental work precluding dentists from assessing enamel status, Note: evaluable is defined as having bilateral assessable mandibular molars, or erosions present in the remaining assessable quadrants. * For healthy controls only, patients cannot have a non-skin cancer history nor presenting for a procedure evaluating reflux symptoms.
Where this trial is running
New York, New York
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Steven Maron, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Steven Maron, MD
- Email: marons@mskcc.org
- Phone: 646-888-6780
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.