Understanding time processing in Huntington's and Alzheimer's diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how patients with Huntington's disease and Alzheimer's disease process time on different scales, specifically focusing on the roles of the striatum and hippocampus. By developing time processing tasks, the study aims to compare the performance of these patients in interval timing, which is crucial for daily functioning. The research will involve symptomatic Huntington's disease gene carriers and patients with Alzheimer's disease, assessing their cognitive abilities related to time perception. The findings could enhance our understanding of cognitive deficits in these conditions and inform future therapeutic approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Huntington's disease gene carriers

  * Patient included in the BioHD protocol
  * Age from 18 to 90 years old
  * Symptomatic patient
  * TFC ≥ 11
  * UHDRS motor\> 5
  * Native language: French
  * Affiliation to a social security or to another social protection
  * Signature of informed consent

    • Patients with Alzheimer's disease
  * MMS from 20 to 26 (included)
  * Age: from 60 to 90 years old
  * Native language: French
  * Progressive deterioration of memory reported by patient or caregiver for more than 6 months
  * Profile at RL /RI 16: no significant improvement with indexing
  * Episodic memory disorder isolated or associated with other cognitive disorders
  * MRI: Atrophy of the median temporal lobe
  * Affiliation to a social security or to another social protection
  * Signature of informed consent

    • Healthy subjects
  * Healthy subject included in the BioHD protocol
  * MMS ≥ 26
  * Age from 18 to 90 years old
  * Native language: French
  * Affiliation to a social security or to another social protection
  * Signature of informed consent

Exclusion Criteria:

* Huntington's disease gene carriers

  * Intellectual deterioration preventing understanding of the protocol
  * Other dementia than Huntington's disease
  * Patient living alone at home
  * Major depression
  * Patient under legal protection
  * Patient deprived of liberty
  * Pregnant or breastfeeding woman, situation known to the investigator
  * Inability to handle an electronic tablet
* Patients with Alzheimer's disease

  * Intellectual deterioration preventing understanding of the protocol
  * Patient living alone at home
  * Sudden onset of memory impairment
  * Early onset of the following symptoms: difficulty in walking, convulsions, changes in behavior
  * Focal neurological characteristics including hemiparesis, sensory loss, visual field deficit
  * Early extrapyramidal sign
  * Other dementia than Alzheimer's disease
  * Major depression
  * Cerebrovascular disease
  * Toxic, metabolic or infectious anomaly
  * Patient under legal protection
  * Patient deprived of liberty
  * Pregnant or breastfeeding woman, situation known to the investigator
  * Inability to handle an electronic tablet
* Healthy subjects

  * Intellectual deterioration preventing understanding of the protocol
  * Known neurological or psychiatric illness
  * Patient under legal protection
  * Subject deprived of liberty
  * Pregnant or breastfeeding woman, situation known to the investigator
  * Inability to handle an electronic tablet

Where it's running

• Assistance Publique Hôpitaux de Paris - Hôpital Henri Mondor
  Créteil, France Recruiting

Study contacts

• Study coordinator: Anne-Catherine BACHOUD-LEVI, MD, PhD
• Email: anne-catherine.bachoud-levi@aphp.fr
• Phone: 01 49 81 23 10

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.