Understanding the tumor microenvironment in ovarian cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to generate organoids from patients with stage III and IV epithelial ovarian cancer to explore the interactions between tumor cells, immune cells, and microbiota within the tumor microenvironment. By utilizing a three-dimensional cell culture system, the study seeks to replicate the essential properties of ovarian tissue in vitro, which may help elucidate the molecular mechanisms behind ovarian cancer progression. The research will involve collecting tumor and adjacent normal tissue from patients undergoing surgical removal of their tumors, allowing for a detailed analysis of the tumor microenvironment and potential therapeutic responses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years
* Age \< 80 years
* Serous ovarian carcinoma
* FIGO Stage III-IV

Exclusion Criteria:

* Ongoing or suspended immunosuppressive therapy within the last 6 months
* Congenital or acquired immunodeficiency
* Immunosuppressive state
* Administration of chemotherapy for another neoplasm in the past 12 months
* Non-epithelial ovarian tumors
* Patients not undergoing surgical intervention
* BMI \> 30
* Absence of Informed Consent

Where it's running

• Università degli Studi di Udine
  Udine, Ud, Italy Recruiting

Study contacts

• Study coordinator: Giuseppe Vizzielli, Prof.
• Email: giuseppe.vizzielli@uniud.it
• Phone: 3403990822

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.