Understanding the genetics of Polycythemia and Thrombocytosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to characterize the clinical features and genetic patterns associated with Polycythemia and Thrombocytosis. Researchers will investigate the genetic mutations that may cause these disorders through genetic and cell biology techniques. Participants will have a small amount of blood drawn for DNA analysis, which will help identify the molecular defects linked to these conditions. The ultimate goal is to pave the way for new therapies to manage or potentially cure these disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Subjects with an elevated hemoglobin concentration (\>18 in males and \>16 in females)
2. Subjects with an elevated platelet count (\>450,000)

Exclusion Criteria:

1. Subjects who have a known acquired cause of polycythemia and thrombocytosis
2. Subjects with heart disease, left to right heart shunt or severe pulmonary disease

Where it's running

• University of Utah
  Salt Lake City, Utah, United States Recruiting

Study contacts

• Principal investigator: Josef T. Prchal, MD — University of Utah
• Study coordinator: Josef T Prchal, MD
• Email: josef.prchal@hsc.utah.edu
• Phone: 801-581-4220

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT06038630

• Impact of Phlebotomy on Heart Rate in Patients with Polycythemia

  This study is testing how having blood drawn regularly affects heart rate and overall well-being in people with polycythemia.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT05396170

• MPNdpoint: Long-term Look at Philadelphia-negative Myeloproliferative Neoplasms

  This study tests how outcomes differ for patients 16 and older with polycythemia vera, essential thrombocythemia, or myelofibrosis by collecting and analyzing clinical and treatment data.

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• Test of bomedemstat for polycythemia vera in adults

  This study tests bomedemstat (MK-3543) to see if it helps people with polycythemia vera reach healthier blood counts compared with standard treatments.

  Recruiting at 5 sites Phase 2/3 Merck Sharp & Dohme LLC · Newark, Delaware and 4 other locations · NCT07722611

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.