Understanding the genetics of Polycythemia and Thrombocytosis
Molecular Biology of Polycythemia and Thrombocytosis
This study is trying to find out how genetics affects Polycythemia and Thrombocytosis by looking at blood samples from people with these conditions to help develop better treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Sex | All |
| Sponsor | University of Utah Academic / other |
| Locations | 1 site (Salt Lake City, Utah) |
| Trial ID | NCT00722527 on ClinicalTrials.gov |
What this trial studies
This observational study aims to characterize the clinical features and genetic patterns associated with Polycythemia and Thrombocytosis. Researchers will investigate the genetic mutations that may cause these disorders through genetic and cell biology techniques. Participants will have a small amount of blood drawn for DNA analysis, which will help identify the molecular defects linked to these conditions. The ultimate goal is to pave the way for new therapies to manage or potentially cure these disorders.
Who should consider this trial
Good fit: Ideal candidates include individuals with elevated hemoglobin or platelet counts without known acquired causes.
Not a fit: Patients with known acquired causes of their conditions or significant heart or pulmonary diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the development of targeted therapies for patients suffering from Polycythemia and Thrombocytosis.
How similar studies have performed: Other studies investigating genetic causes of blood disorders have shown promise, suggesting that this approach could yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Subjects with an elevated hemoglobin concentration (\>18 in males and \>16 in females) 2. Subjects with an elevated platelet count (\>450,000) Exclusion Criteria: 1. Subjects who have a known acquired cause of polycythemia and thrombocytosis 2. Subjects with heart disease, left to right heart shunt or severe pulmonary disease
Where this trial is running
Salt Lake City, Utah
- University of Utah — Salt Lake City, Utah, United States (Recruiting)
Study contacts
- Principal investigator: Josef T. Prchal, MD — University of Utah
- Study coordinator: Josef T Prchal, MD
- Email: josef.prchal@hsc.utah.edu
- Phone: 801-581-4220
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.