Understanding the genetic causes of Biliary Atresia
Molecular Characterization for Understanding Biliary Atresia
This study is trying to find out the genetic causes of Biliary Atresia in newborns to help improve understanding and future treatments for this serious liver condition.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Sex | All |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France Government |
| Locations | 2 sites (Paris, De and 1 other locations) |
| Trial ID | NCT04272515 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the molecular mechanisms behind Biliary Atresia (BA), a rare but serious condition that leads to liver complications in newborns. Researchers will collect fluid samples, explanted liver tissue, and dermal biopsies from patients diagnosed with BA to conduct genetic and molecular analyses. The goal is to identify specific genes and cellular pathways that contribute to the development of this disease, which is currently poorly understood. By uncovering these molecular factors, the study hopes to enhance the understanding of BA and potentially inform future treatment strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are infants diagnosed with Biliary Atresia and their parents.
Not a fit: Patients without a confirmed diagnosis of Biliary Atresia will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with Biliary Atresia.
How similar studies have performed: While Biliary Atresia is a rare condition, similar studies investigating genetic factors in other diseases have shown promise, indicating potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * confirmed diagnosis of biliary atresia in patients * parents of BA patients Exclusion Criteria: * no
Where this trial is running
Paris, De and 1 other locations
- Hopital Necker enfants malades — Paris, De, France (Recruiting)
- PRC Inserm — Paris, France (Not_yet_recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.