Understanding the genetic causes of biliary atresia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project evaluates the developmental and genetic basis of biliary atresia, a leading cause of liver failure in newborns. It aims to differentiate between isolated and syndromic forms of the disease by analyzing genetic susceptibility and environmental influences. The study will involve collecting DNA samples from 1100 biliary atresia patients and their families to identify candidate genes associated with the condition. The findings may provide insights into the mechanisms behind biliary atresia and its related birth defects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* living individuals who were diagnosed with Biliary Atresia and received or are about to receive a liver transplant from multiple participating centers (Children's Hospital of Pittsburgh, Kings College Hospital, Children's Hospital of Birmingham, and Hospital Sírio-Libanês).

Exclusion Criteria:

* No child participant in the care of the state will be enrolled, nor will patients in the care of temporary or informal guardians be enrolled

Where it's running

• UPMC Children's Hospital of Pittsburgh
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Study coordinator: Morgan L Paul, BSN
• Email: Morgan.Paul2@upmc.edu
• Phone: 4126928472

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Umbilical cord stem cells added during Kasai to help biliary atresia

  This early-stage trial tests whether injecting umbilical cord mesenchymal stem cells during Kasai portoenterostomy is safe and helpful for infants with biliary atresia.

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• See if a computer program can help diagnose cholestasis in newborns using parent-provided stool images

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• Indocyanine green for diagnosing biliary atresia

  This test tries to see if a harmless fluorescent dye (indocyanine green) can show whether infants under 3 months with cholestasis have blocked bile ducts (biliary atresia).

  Recruiting Phase 1/2 Boston Children's Hospital · Boston, Massachusetts · NCT07513038

• Using near-infrared ICG dye to check bile flow in newborns with cholestasis

  We will give eligible newborns a single IV dose of indocyanine green (ICG) to see if the dye appears in their diapers, which would indicate bile is flowing and the bile ducts are open.

  Recruiting Early Phase 1 University of Alabama at Birmingham · Birmingham, Alabama · NCT07250854

• High-MCT nutritional support for infants with biliary atresia

  We will test whether giving a high medium-chain triglyceride (MCT) formula before and after Kasai surgery helps infants with biliary atresia grow better and recover faster than standard feeding.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT06764082

• Using oral antibiotics to prevent cholangitis after liver surgery in infants

  This study is testing if giving oral antibiotics to infants after liver surgery can help prevent cholangitis, compared to those who don’t receive the antibiotics.

  Recruiting Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT05925309

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.