Understanding the genetic causes of biliary atresia
Coordinating Center- Mapping Disease Pathways for Biliary Atresia
This study is trying to find out the genetic causes of biliary atresia by collecting DNA samples from babies with the condition and their families to see what might lead to this serious liver problem.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1100 (estimated) |
| Sex | All |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Trial ID | NCT03273049 on ClinicalTrials.gov |
What this trial studies
This project evaluates the developmental and genetic basis of biliary atresia, a leading cause of liver failure in newborns. It aims to differentiate between isolated and syndromic forms of the disease by analyzing genetic susceptibility and environmental influences. The study will involve collecting DNA samples from 1100 biliary atresia patients and their families to identify candidate genes associated with the condition. The findings may provide insights into the mechanisms behind biliary atresia and its related birth defects.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with biliary atresia who are receiving or are about to receive a liver transplant.
Not a fit: Patients who are not diagnosed with biliary atresia or those under state care will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for biliary atresia.
How similar studies have performed: While there have been studies on biliary atresia, this approach focusing on genetic pathways is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * living individuals who were diagnosed with Biliary Atresia and received or are about to receive a liver transplant from multiple participating centers (Children's Hospital of Pittsburgh, Kings College Hospital, Children's Hospital of Birmingham, and Hospital Sírio-Libanês). Exclusion Criteria: * No child participant in the care of the state will be enrolled, nor will patients in the care of temporary or informal guardians be enrolled
Where this trial is running
Pittsburgh, Pennsylvania
- UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States (Recruiting)
Study contacts
- Study coordinator: Morgan L Paul, BSN
- Email: Morgan.Paul2@upmc.edu
- Phone: 4126928472
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.