Understanding the genetic and environmental factors of esophageal atresia
Oesomics Anastomose Molecular Signatures of Esophageal Atresia Comparison of Biopsies Taken During the First Year of Life With Those Taken During Anastomosis
NA · University Hospital, Lille · NCT06073158
This study is trying to find out how genes and the environment contribute to esophageal atresia by looking at tissue samples from surgeries to help improve care for patients with this condition.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 1 Day to 1 Year |
| Sex | All |
| Sponsor | University Hospital, Lille (other) |
| Locations | 1 site (Lille) |
| Trial ID | NCT06073158 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the molecular signatures associated with esophageal atresia (EA) by analyzing esophageal biopsies collected during surgical anastomosis. It focuses on understanding the role of epigenetic and environmental factors in the development of EA, as current genetic testing identifies causative abnormalities in less than 10% of cases. By examining these biopsies, the study seeks to uncover the underlying mechanisms of EA, which may lead to improved clinical care and outcomes for affected patients.
Who should consider this trial
Good fit: Ideal candidates for this study are infants born with esophageal atresia who are undergoing surgical anastomosis at Lille hospital.
Not a fit: Patients whose parents refuse to participate in the study will not benefit from this research.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of esophageal atresia, leading to better diagnostic and therapeutic strategies for patients.
How similar studies have performed: While there have been studies exploring genetic factors in esophageal atresia, this approach focusing on epigenetic and environmental contributions is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Anastomosis group : Born with esophageal atresia Anastomosis performed in Lille hospital Parents consent - Control group : Born with esophageal atresia Exclusion Criteria: * Both groups : Parents refusing to participate in the study
Where this trial is running
Lille
- CHU Lille — Lille, France (RECRUITING)
Study contacts
- Study coordinator: Mélanie Leroy, PhD
- Email: melanie.leroy@chu-lille.fr
- Phone: +33625372349
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Esophageal Atresia, esophageal atresia, epigenetic, proteomics, metabolomics