Understanding the characteristics of status epilepticus in the French West Indies and French Guiana

Assessment of Adults Epidemiological Characteristics of Status Epilepticus in the French West Indies and in French Guiana

This study is trying to learn more about status epilepticus in adults in the French West Indies and French Guiana by looking at their symptoms, causes, and how they respond to treatment.

Quick facts

• Study type: Observational
• Enrollment: 241 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: University Hospital Center of Martinique (Academic / other)
• Locations: 4 sites (Cayenne, French Guiana and 3 other locations)
• Trial ID: NCT05246566 on ClinicalTrials.gov

What this trial studies

This observational study aims to gather epidemiological data on status epilepticus (SE) in adults treated in the French West Indies and French Guiana. It will assess the clinical, etiological, and prognostic characteristics of SE, which is a serious neurological emergency. The study will involve adult patients who have experienced SE and will collect data on their conditions, treatment, and outcomes. The goal is to fill the gap in knowledge regarding the prevalence and causes of SE in this specific region.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who have been treated for status epilepticus in the specified regions.

Not a fit: Patients who do not have status epilepticus or are under 18 years old may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of status epilepticus, potentially reducing morbidity and mortality associated with this condition.

How similar studies have performed: While there is limited data on status epilepticus in these regions, similar studies in other areas have highlighted the importance of understanding its epidemiology and prognosis.

Eligibility criteria

Inclusion Criteria:

* Adult patients (≥ 18 years old) treated for SE by SAMU/SMUR and by emergencies or intensive care in the French West Indies and French Guiana.
* Covered for suspected or SE diagnosis defined by one of the following:

  * a prolonged generalized tonic-clonic crisis lasting more than 5 minutes and accompanied by impaired consciousness or at least 2 generalized tonic-clonic crisis without return to normal consciousness between crisis.
  * a focal convulsive crisis (motor or not) with disturbances of consciousness which lasts beyond 10 minutes or crisis which are repeated (≥ 2) at short intervals without recovery of interictal consciousness.
  * a focal convulsive crisis (motor or not) without alteration of consciousness that lasts beyond 10 to 15 minutes.
  * an absence-type crisis that lasts longer than 10 to 15 minutes.
  * a myoclonic, clonic and tonic crisis that lasts longer than 10 to 15 minutes.
  * a coma with an epileptic cause diagnosed on an EEG.
* Patient if he is able to, or representative of the patient in case of incapacity, having given his agreement for the use of his medical data for this research.

Exclusion Criteria:

* Age \< 18 years old
* Absence of consent from the patient, or representative to the use of the data for the research.
* Patient whose main residence is not in the department where the study is taking place (vacationer for example).

Where this trial is running

Cayenne, French Guiana and 3 other locations

• Hospital of Cayenne — Cayenne, French Guiana, France (Recruiting)
• Hospital of Basse-Terre — Basse-Terre, Guadeloupe, France (Not_yet_recruiting)
• University Hospital Center of Guadeloupe — Pointe-à-Pitre, Guadeloupe, France (Not_yet_recruiting)
• University Hospital Center of Martinique — Fort-de-France, Martinique, France (Recruiting)

Study contacts

• Principal investigator: Florian Negrello, MD — University Hospital Center of Martinique
• Study coordinator: Florian Negrello, MD

Conditions Status Epilepticus; Epilepsy; Epidemiology; Pronostic