Understanding the causes of cerebral small vessel disease
Imaging the Pathogenesis of Cerebral Small Vessel Disease
Johns Hopkins University · NCT05703386
This study is trying to understand what causes cerebral small vessel disease by looking at brain changes in people who have had a stroke and are at risk for further issues over the next year.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Johns Hopkins University (other) |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT05703386 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the pathogenesis of cerebral small vessel disease (CSVD) by recruiting individuals at risk for white matter hyperintensities (WMH) progression. Participants will undergo serial MRI scans to assess changes in the brain's micro-structural integrity and blood-brain barrier disruption over a period of 1.25 years. The study will focus on patients with a history of ischemic stroke and vascular risk factors, utilizing various MRI biomarkers to gain insights into the relationship between CSVD and cognitive impairment.
Who should consider this trial
Good fit: Ideal candidates include individuals with a history of ischemic stroke, at least one vascular risk factor, and evidence of cerebral small vessel disease on MRI.
Not a fit: Patients who are unable to complete the required MRI scans or do not have a history of stroke or vascular risk factors may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive decline associated with cerebral small vessel disease.
How similar studies have performed: Other studies have shown success in using MRI to track changes in cerebral small vessel disease, indicating that this approach is supported by prior research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical or radiographic evidence of ischemic stroke * One vascular risk factor (hypertension, hyperlipidemia, or diabetes) * Evidence of cerebral small vessel disease on MRI Exclusion Criteria: * Inability to complete 3 research MRI scans over 1.25 years
Where this trial is running
Baltimore, Maryland
- Kennedy Krieger Institute — Baltimore, Maryland, United States (RECRUITING)
Study contacts
- Principal investigator: Richard Leigh, MD — Johns Hopkins University
- Study coordinator: Sera Chase
- Email: schase15@jh.edu
- Phone: 410-502-5355
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Ischemic Stroke, Hypertension, Hyperlipidemias, Diabetes, Cerebral small vessel disease, Vascular cognitive impairment and dementia, White matter hyperintensities, Blood-brain barrier