Understanding the causes of cerebral small vessel disease
Official title: Imaging the Pathogenesis of Cerebral Small Vessel Disease
Run by Johns Hopkins University · NCT05703386 · Data updated 2026-11-12
This study is trying to understand what causes cerebral small vessel disease by looking at brain changes in people who have had a stroke and are at risk for further issues over the next year.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Status | Recruiting |
| Started | November 8, 2022 |
| Main results expected | March 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | March 3, 2026 |
| Trial ID | NCT05703386 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with a history of ischemic stroke, at least one vascular risk factor, and evidence of cerebral small vessel disease on MRI.
✕Probably not a fit
Patients who are unable to complete the required MRI scans or do not have a history of stroke or vascular risk factors may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the pathogenesis of cerebral small vessel disease (CSVD) by recruiting individuals at risk for white matter hyperintensities (WMH) progression. Participants will undergo serial MRI scans to assess changes in the brain's micro-structural integrity and blood-brain barrier disruption over a period of 1.25 years. The study will focus on patients with a history of ischemic stroke and vascular risk factors, utilizing various MRI biomarkers to gain insights into the relationship between CSVD and cognitive impairment.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive decline associated with cerebral small vessel disease.
How similar studies have gone: Other studies have shown success in using MRI to track changes in cerebral small vessel disease, indicating that this approach is supported by prior research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical or radiographic evidence of ischemic stroke * One vascular risk factor (hypertension, hyperlipidemia, or diabetes) * Evidence of cerebral small vessel disease on MRI Exclusion Criteria: * Inability to complete 3 research MRI scans over 1.25 years
Where it's running
-
Kennedy Krieger Institute
Baltimore, Maryland, United States Recruiting
Study contacts
- Principal investigator: Richard Leigh, MD — Johns Hopkins University
- Study coordinator: Sera Chase
- Email: schase15@jh.edu
- Phone: 410-502-5355
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.