Understanding sepsis in ICU patients using advanced data analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with sepsis in Intensive Care Units (ICUs) to explore the complex interactions between hosts and pathogens. By utilizing state-of-the-art analytical algorithms, including machine learning and multidimensional modeling, the study aims to analyze large datasets to identify digital biomarkers. A case-control design will compare data patterns from patients with sepsis to those without, potentially leading to novel diagnostic approaches for sepsis. The study is conducted across multiple centers in Switzerland, specifically within university hospitals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients admitted to an ICU on a Swiss University Hospital.
* Patients expected to stay at least 24h on the ICU

Inclusion Criteria (cases)

* Present at admission to ICU or subsequent development of sepsis 3.0 criteria

Inclusion Criteria (controls)

* Patients not fulfilling sepsis definition during the ICU stay

Exclusion Criteria:

* Decline of general consent or any other negative statement against using data for research.
* Patients with a clear elective stay on the ICUs.

Where it's running

• Clinical Microbiology, University Hospital Basel
  Basel, Switzerland Recruiting
• Infectious Diseases and Hospital Epidemiology, University Hospital Basel
  Basel, Switzerland Recruiting
• Medical Intensive Care Unit; University Hospital Basel
  Basel, Switzerland Recruiting
• Surgical Intensive Care Unit, University Hospital Basel
  Basel, Switzerland Recruiting
• Institute for Infectious Diseases, University of Bern
  Bern, Switzerland Recruiting
• Division Infectious Diseases, University Hospital Bern
  Bern, Switzerland Recruiting

Study contacts

• Principal investigator: Adrian Egli, PD Dr. — Clinical Microbiology, University Hospital Basel
• Study coordinator: Adrian Egli, PD Dr.
• Email: adrian.egli@usb.ch
• Phone: +41 61 556 5749

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ruta C and Vitamin C in Sepsis: Adding antioxidants to standard care

  This trial tests whether adding Ruta C (rutin plus vitamin C) or vitamin C alone to standard sepsis treatment helps adults in the ICU stay shorter and recover better.

  Recruiting Ain Shams University · Cairo, Cairo Governorate · NCT07922213

• Early detection of sepsis-related blood clotting problems in severe burn patients

  This study tests how well the JAAM-2 score can detect sepsis-induced coagulopathy early in adults with severe burns who develop sepsis in the ICU.

  Recruiting Center for Traumatology and Major Burns, Ben Arous · Tunis · NCT07914205

• Neutrophil EMR3 as a biomarker for sepsis in ICU patients

  Researchers will test whether measuring EMR3 on neutrophils helps diagnose sepsis, monitor progression, and predict outcomes in adults in Chinese ICUs.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT07896018

• Thymalfasin added to standard care for adults with sepsis and immune dysfunction

  This study tests whether thymosin alpha-1 helps restore immune function in adults with sepsis who have weakened immunity.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07866118

• Multicenter group study of sepsis and ARDS in China

  This study tests how sepsis and ARDS differ among adults across several Chinese hospitals and builds a biobank to understand why some patients do better or worse.

  Recruiting at 24 sites Shanghai Zhongshan Hospital · Xiamen, Fujian and 23 other locations · NCT07863908

• Non-invasive hemodynamic guidance for sepsis care on medical wards

  This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.

  Recruiting at 2 sites Regione del Veneto - AULSS n. 7 Pedemontana · Pisa, Pisa and 1 other locations · NCT07863323

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.