Understanding repetitive behaviors in Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares patterns of repetitive behaviors across three groups: individuals with Alzheimer’s disease, healthy controls, and a single patient with anterograde amnesia. Repetitive behaviors are measured using the Stereotypy Rating Inventory, which covers eating, wandering, speech, movements, and daily routines. Researchers will analyze how frequency and severity relate to cognitive status and anosognosia, with a focus on identifying potential correlations. The study does not assign an intervention; rather, it characterizes behavioral symptoms and their context. Eligibility requires available caregiver support and specific MMSE scores to define subgroups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

I- RB+ (n=42) and RB- (n=30) groups :

1. MMSE \> 20
2. 1 reliable family caregiver identified per patient
3. Patients under legal protection (guardianship/curatorship) or not
4. Selection:

4.a. AD patients with an SRI score \> 0 will constitute the RB+ subgroup. 4.b. Only the first 30 patients included will undergo V2, V3, and V4. The first 30 AD patients included with an SRI score = 0 will constitute the RB- subgroup.

II- Control group: healthy subjects (n=30)

1. Healthy subjects
2. MMSE ≥ 26/30
3. Men and women matched to AD patients in terms of age and sociocultural level.
4. Healthy subjects will be included by the CMRR in Limoges

III- Control group: Patient with anterograde amnesia (AA) (n=1):

1. The patient with anterograde amnesia is a patient who participated in the ANISAAFORNIX study (another study submitted by the investigator) and is included in this study due to rich RB symptomatology. He is a 54-year-old man with lesions of the fornix following complications from neurosurgery, which led to severe anterograde amnesia. This patient does not have AD.
2. This patient is under legal protection (guardianship).
3. Patient monitored and included at the CMRR in Limoges.

Exclusion Criteria: I- RB+ and RB- groups and healthy subjects:

1. Isolated participants (without an identified caregiver) (RB+ and RB- groups)
2. Participants must not have a history of alcohol or other substance dependence in the past 12 months.
3. Participants must not have any other neurological condition (with the exception of patients with AA anterograde amnesia). Any history of moderate to severe head trauma, stroke, or developmental disorders is a criterion for exclusion.

Where it's running

• Esquirol Hospital Center
  Limoges, New Aquitaine, France Recruiting

Study contacts

• Study coordinator: Clément POLIN, PhD neuropsychology
• Email: clement.polin@ch-esquirol-limoges.fr
• Phone: 555431215

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.