Understanding recovery from Cushing syndrome after surgery
Official title: Recovery From Cushing Syndrome and Mild Autonomous Cortisol Secretion (MACS)
Run by Mayo Clinic · NCT04543253 · Data updated 2026-11-12
This study looks at how people with Cushing syndrome recover after surgery and whether a special biofeedback program can help with symptoms after stopping steroid treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 700 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | July 25, 2019 |
| Main results expected | December 2030 |
| Study ends | December 2030 |
| Registry record updated | September 18, 2026 |
| Trial ID | NCT04543253 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and above with a new diagnosis of Cushing syndrome planning for curative surgery.
✕Probably not a fit
Patients who have received systemic supraphysiological glucocorticoids within one month prior to enrollment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the recovery process in patients with Cushing syndrome (CS) following curative surgery. It will assess pre- and post-surgical factors that influence the duration and severity of glucocorticoid withdrawal syndrome (GWS) and characterize the recovery of symptoms related to hypercortisolism. The study will involve the recruitment of 100 adult patients diagnosed with CS of various subtypes, who will be monitored for up to two years. Additionally, the impact of a MUSE biofeedback intervention on GWS severity will be evaluated compared to standard care.
Why it matters
Potential benefit: If successful, this study could improve the management and recovery outcomes for patients undergoing surgery for Cushing syndrome.
How similar studies have gone: While there have been small retrospective studies on recovery from Cushing syndrome, this study's specific approach to assessing GWS and recovery is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. age 18 and above, 2. new diagnosis of CS of any of the three subtypes (pituitary, adrenal or ectopic CS), and MACS, 3. planning for a curative surgery 4. ability to provide informed consent. Exclusion Criteria: 1. systemic supraphysiological GC for any reason within 1 month of enrollment, for more than 2 weeks, 2. inability to provide informed consent
Where it's running
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Mayo Clinic
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Irina Bancos, MD, MS — Mayo Clinic
- Study coordinator: Vanessa Fell, MA
- Email: fell.vanessa@mayo.edu
- Phone: 507-266-6068
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.