Understanding PrEP use among Black men and transwomen in the Southeastern US

PrEP Connected Study

Not applicable Interventional University of Connecticut · NCT04832477

This study is trying to understand how stigma and substance use affect Black men and transwomen in the Southeastern US from using PrEP to prevent HIV, especially during the COVID-19 pandemic.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment500 (estimated)
Ages18 Years and up
SexMale
SponsorUniversity of Connecticut Academic / other
Locations1 site (Atlanta, Georgia)
Trial IDNCT04832477 on ClinicalTrials.gov

What this trial studies

This research aims to explore the stigma and substance use barriers affecting pre-exposure prophylaxis (PrEP) uptake among Black sexual minority men in the Southeastern United States. The study focuses on assessing how these factors influence PrEP linkage, adherence, and persistence, particularly in the context of the COVID-19 pandemic. By providing evidence-based counseling to address these barriers, the study seeks to enhance PrEP engagement among substance-using individuals in this high-risk population.

Who should consider this trial

Good fit: Ideal candidates for this study are Black men aged 18 and older who report recent substance use and have engaged in condomless anal sex with men.

Not a fit: Patients who do not identify as Black or who do not report recent substance use may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could significantly increase PrEP uptake and adherence among Black sexual minority men, thereby reducing HIV transmission rates in this vulnerable group.

How similar studies have performed: While there have been studies addressing PrEP use in various populations, this specific focus on stigma and substance use among Black sexual minority men is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Men (based on male sex assignment at birth)
* Age 18 or older
* Identify as Black, African-American, Afro-Brazilian, Afro-Carribean, or African diaspora,
* Report condomless anal sex with man in past six months
* Test HIV negative
* Report recent (\<3 months) substance use
* Positive drug toxicology for substance use

Exclusion Criteria:

-

Where this trial is running

Atlanta, Georgia

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions HIV SeropositivitySubstance UseSTIStigma, Social
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.