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Clinical trial No longer in our active list Interventional Ages 18 and up Men only

Understanding PrEP use among Black men and transwomen in the Southeastern US

Official title: PrEP Connected Study

Run by University of Connecticut · NCT04832477 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is trying to understand how stigma and substance use affect Black men and transwomen in the Southeastern US from using PrEP to prevent HIV, especially during the COVID-19 pandemic.

More Substance Use trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexMen only
Enrollment500 (estimated)
SponsorUniversity of Connecticut
Academic / other
Locations1 site (Atlanta, Georgia)
Trial IDNCT04832477 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are Black men aged 18 and older who report recent substance use and have engaged in condomless anal sex with men.

Probably not a fit

Patients who do not identify as Black or who do not report recent substance use may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to explore the stigma and substance use barriers affecting pre-exposure prophylaxis (PrEP) uptake among Black sexual minority men in the Southeastern United States. The study focuses on assessing how these factors influence PrEP linkage, adherence, and persistence, particularly in the context of the COVID-19 pandemic. By providing evidence-based counseling to address these barriers, the study seeks to enhance PrEP engagement among substance-using individuals in this high-risk population.

Why it matters

Potential benefit: If successful, this study could significantly increase PrEP uptake and adherence among Black sexual minority men, thereby reducing HIV transmission rates in this vulnerable group.

How similar studies have gone: While there have been studies addressing PrEP use in various populations, this specific focus on stigma and substance use among Black sexual minority men is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Men (based on male sex assignment at birth)
* Age 18 or older
* Identify as Black, African-American, Afro-Brazilian, Afro-Carribean, or African diaspora,
* Report condomless anal sex with man in past six months
* Test HIV negative
* Report recent (\<3 months) substance use
* Positive drug toxicology for substance use

Exclusion Criteria:

-

Where it's running

  • SHARE Project
    Atlanta, Georgia, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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HIV Seropositivity 2Substance Use 565STI 2Stigma, Social 3University of Connecticut 13
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.