Understanding pain modulation in hemophilia patients
Conditioned Pain Modulation in Patients With Hemophilic Arthropathy. A Cross-sectional Cohort Study
Investigación en Hemofilia y Fisioterapia · NCT06267209
This study is trying to understand how pain works in people with hemophilia, especially those with joint problems, by looking at how their feelings about pain and anxiety might affect their pain levels.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 51 (estimated) |
| Ages | 20 Years to 65 Years |
| Sex | Male |
| Sponsor | Investigación en Hemofilia y Fisioterapia (network) |
| Locations | 1 site (Oviedo, Principality of Asturias) |
| Trial ID | NCT06267209 on ClinicalTrials.gov |
What this trial studies
This observational study aims to describe conditioned pain modulation in patients with hemophilia, focusing on those with hemophilic arthropathy. It will recruit 51 patients from three regions in Spain and assess their pain modulation using an ischemic technique to measure pain pressure thresholds. The study will also evaluate factors such as kinesiophobia, catastrophizing, and anxiety that may influence pain perception. The goal is to identify predictive models for conditioned pain modulation in this patient population.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with hemophilia A or B and bilateral hemophilic ankle arthropathy.
Not a fit: Patients with recent ankle hemarthrosis or those currently taking analgesics or undergoing physiotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients with hemophilia.
How similar studies have performed: While studies on pain modulation exist, this specific approach in hemophilia patients is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with hemophilia A or B. * Patients over 18 years of age. * Persons with a medical diagnosis of bilateral hemophilic ankle arthropathy. * Patients with clinical assessment by Hemophilia Joint Health Score (\>4 points). * Persons with hemophilia on prophylactic treatment with FVIII / FIX coagulation concentrates or monoclonal antibodies. * Have signed the informed consent document. Exclusion Criteria: * Patients with neurological or cognitive alterations that prevent the comprehension of the questionnaires and physical tests. * Patients who have had an ankle hemarthrosis in the 6 months prior to the start of the study. * Patients who have taken analgesic or anti-inflammatory drugs in the 30 days prior to the study. * Patients who are undergoing an intervention (physiotherapeutic or orthopedic) at the time of the study.
Where this trial is running
Oviedo, Principality of Asturias
- University of Oviedo — Oviedo, Principality of Asturias, Spain (RECRUITING)
Study contacts
- Study coordinator: Rubén Cuesta-Barriuso, PhD
- Email: cuestaruben@uniovi.es
- Phone: 607547274
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hemophilia, Haemophilia, Joint pain, Conditioned pain modulation, Kinesiophobia, Catastrophism, Anxiety