Understanding Myocardial Ischemia Without Blocked Arteries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance knowledge about myocardial ischemia caused by non-obstructive coronary artery disease. It will enroll patients referred for coronary physiological assessment, utilizing pressure-flow measurements and acetylcholine tests to evaluate coronary hemodynamics. The study will diagnose microcirculatory dysfunction and vasomotor disorders based on established criteria and adjust medical therapy accordingly. Patients will be followed up over a period of five years to assess their angina status using the Seattle Questionnaire.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written informed consent available.
* Age ≥ 18 years.
* Patient eligible for invasive physiological assessment with adenosine and / or acetylcholine.

Exclusion Criteria:

* Hemodynamic instability.
* Anticipated technical issues for physiology wire measurements.
* Culprit vessel of acute coronary syndrome
* Contraindications for adenosine administration.
* Contraindications for acetylcholine test.
* Reduced life expectancy (less than 1 year).

Where it's running

• Hospital Clinico San Carlos
  Madrid, Spain Recruiting

Study contacts

• Principal investigator: Hernan Mejia-Renteria, MD, PhD — Department of Cardiology, Hospital Clinico San Carlos
• Study coordinator: Hernan Mejia-Renteria, MD, PhD
• Email: hmejiarenteria@gmail.com
• Phone: +34 913303283

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.