Understanding Muscle Regeneration in ICU Survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the mechanisms behind muscle weakness in patients who have survived critical illnesses, particularly focusing on the role of satellite cells in muscle regeneration. It aims to analyze the function and structure of these cells and their organelles, especially mitochondria, through advanced microscopic techniques and bioenergetics. By isolating satellite cells from muscle biopsies of critically ill patients, the study seeks to uncover the pathogenesis of muscle weakness and potential therapeutic targets for improving recovery.

Why it matters

Who can join: the full rules

Eligibility Criteria for group of Critically ill patients:

Inclusion Criteria:

* Critically ill patients receiving mechanical ventilation, to be enrolled within 72 hours of admission, who are likely to need 7 days or more of ICU stay
* Sudden onset of disease, which can be determined in time (such as trauma, stroke, sudden cardiac arrest etc.)
* Informed consent signed by patient or patient's representative

Exclusion Criteria:

* Unlikely to survive 6 months
* Premorbid downslope functional trajectory or poor performance status (ECOG Gr. 3 or worse) or baseline functional status unknown
* Bleeding disorder (INR≥1.5 or PLT\< that would preclude muscle biopsies)
* Known mitochondrial disease
* Endocrine crisis as a reason for admission
* Pregnant women

Eligibility Criteria for a control group:

Elective hip surgery patients with a very good to excellent performance status, only limited to joint pain (ECOG 0)

Where it's running

• Charles University
  Prague, Czech Republic, Czechia Recruiting

Study contacts

• Study coordinator: Adéla Krajčová, MD, PhD
• Email: adela.krajcova@lf3.cuni.cz
• Phone: 00420774732499

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.