Understanding muscle fatigue in older individuals with and without HIV
Official title: Skeletal Muscle Energetics and Fatiguability in Older Individuals
Run by Johns Hopkins University · NCT04142047 · Data updated 2026-11-12
This study is trying to see how muscle problems affect exercise fatigue in older adults with and without HIV.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 60 Years to 90 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Status | Recruiting |
| Started | September 5, 2019 |
| Main results expected | July 1, 2027 |
| Study ends | July 1, 2027 |
| Registry record updated | June 8, 2026 |
| Trial ID | NCT04142047 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 60 and older, including both HIV-positive participants on stable antiretroviral therapy and HIV-negative participants.
✕Probably not a fit
Patients with significant cardiovascular, pulmonary, or orthopedic diseases that limit exercise capacity may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research investigates the relationship between metabolic abnormalities in calf muscles and exercise fatigue in older adults, specifically comparing those living with HIV to those without. The study employs non-invasive techniques such as magnetic resonance imaging (MRI) and spectroscopy (MRS) to assess muscle metabolites and fat content, alongside blood samples to evaluate inflammation levels. By identifying the underlying factors contributing to fatigue, the study aims to enhance our understanding of exercise limitations in this population.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for fatigue and exercise limitations in older adults living with HIV.
How similar studies have gone: While this study addresses a specific population, similar approaches using MRI and MRS have shown promise in understanding muscle metabolism and fatigue in various conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants who are \>= 60 years of age * HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies). * HIV serostatus negative participants Exclusion Criteria: * Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent * Contraindications to MRI * Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity * Significant lower extremity peripheral vascular disease. * Weight greater than 350 lbs * Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.
Where it's running
-
Johns Hopkins Hospital
Baltimore, Maryland, United States Recruiting
Study contacts
- Principal investigator: Robert G Weiss, MD — Johns Hopkins University
- Study coordinator: Maria Esteban, RN, BSN
- Email: mesteba1@jh.edu
- Phone: 410-955-1160
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Evaluating community delivery of HIV treatment for newly diagnosed individuals
This study is testing if providing HIV treatment in community settings can help newly diagnosed individuals in Uganda stick to their care and achieve better health outcomes.
-
Camino HIV Prevention and Care Study
This study tests a combined legal and peer-support program to help Latin American adults in DC and the Bay Area improve HIV testing, PrEP use, and care engagement.
-
VH4367310 in healthy adults: testing single increasing doses for safety and how it behaves in the body
This study tests a single rising dose of VH4367310, a cabotegravir prodrug, to see how it behaves in the body and how safe and tolerable it is in healthy adults aged 18 to 55.
-
Project SHIELD 2.0: Police Education to Support Public Health in Kentucky
Aimed at police in Kentucky, this program tests whether SHIELD training given to officers, with health workers helping deliver it, can reduce drug-related arrests and steer people who use drugs toward MOUD and other health services.
-
New ways to diagnose lymphoma and multicentric Castleman disease in people living with HIV
This study tests a quick, point-of-care nucleic acid test to help diagnose lymphoma and multicentric Castleman disease in people living with HIV in sub-Saharan Africa.
-
Online cohort of sexual and gender minorities testing digital support to boost PrEP and ART use
In Brazil, sexually and gender diverse adults are being followed online to see if weekly WhatsApp reminders help people stick to PrEP or ART.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.