Understanding muscle and metabolic issues in young people with spastic cerebral palsy
Muscle-tendon Pathology, Metabolic Dysregulation and Chronic Inflammation in Adolescents and Young Adults With Moderate to Severe Spastic Cerebral Palsy
This study is testing how muscle and health issues affect young people with spastic cerebral palsy and whether a special tricycle training program can help improve their fitness and overall health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 14 Years to 30 Years |
| Sex | All |
| Sponsor | University of Graz Academic / other |
| Locations | 1 site (Graz) |
| Trial ID | NCT06330922 on ClinicalTrials.gov |
What this trial studies
This project aims to investigate muscle-tendon pathology and the risk of cardiometabolic diseases in young individuals aged 14 to 30 with moderate to severe spastic cerebral palsy. The study will compare these individuals with their less affected peers and healthy controls to understand the impact of physical inactivity on muscle function and inflammation. Additionally, a 12-week training intervention using special tricycles will be implemented to assess potential adaptations in their muscular and cardiorespiratory systems. The findings could provide insights into the health challenges faced by this population and inform future interventions.
Who should consider this trial
Good fit: Ideal candidates are adolescents and young adults aged 14 to 30 with moderate to severe spastic cerebral palsy.
Not a fit: Patients with other forms of cerebral palsy or recent orthopedic surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of health risks associated with spastic cerebral palsy.
How similar studies have performed: While there is limited information on similar studies, the focus on muscle-tendon pathology and cardiometabolic risk in this specific population is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * spastic cerebral palsy * mildly, moderately or severly affected (Gross Motor Function Classification System level I-IV) * age range 14 - 30 years * ability to accept and follow verbal instructions * strong communication skills * sufficient vision (visual function that enables safe movement with reference to people and obstacles) * less than 15 hours of experience with the Frame Runners; healthy peers in the same age range Exclusion Criteria: * other forms of cerebral palsy * orthopaedic surgery in the last 12 months * Botulinum toxin application in the last 6 months
Where this trial is running
Graz
- Institute of Human Movement Science, Sport and Health, University of Graz — Graz, Austria (Recruiting)
Study contacts
- Principal investigator: Annika Kruse, Dr. — Institute of Human Movement Science, Sport and Health, University of Graz
- Study coordinator: Annika Kruse, Dr.
- Email: annika.kruse@uni-graz.at
- Phone: 00433163802329
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.