Understanding muscle and metabolic issues in young people with spastic cerebral palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to investigate muscle-tendon pathology and the risk of cardiometabolic diseases in young individuals aged 14 to 30 with moderate to severe spastic cerebral palsy. The study will compare these individuals with their less affected peers and healthy controls to understand the impact of physical inactivity on muscle function and inflammation. Additionally, a 12-week training intervention using special tricycles will be implemented to assess potential adaptations in their muscular and cardiorespiratory systems. The findings could provide insights into the health challenges faced by this population and inform future interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* spastic cerebral palsy
* mildly, moderately or severly affected (Gross Motor Function Classification System level I-IV)
* age range 14 - 30 years
* ability to accept and follow verbal instructions
* strong communication skills
* sufficient vision (visual function that enables safe movement with reference to people and obstacles)
* less than 15 hours of experience with the Frame Runners; healthy peers in the same age range

Exclusion Criteria:

* other forms of cerebral palsy
* orthopaedic surgery in the last 12 months
* Botulinum toxin application in the last 6 months

Where it's running

• Institute of Human Movement Science, Sport and Health, University of Graz
  Graz, Austria Recruiting

Study contacts

• Principal investigator: Annika Kruse, Dr. — Institute of Human Movement Science, Sport and Health, University of Graz
• Study coordinator: Annika Kruse, Dr.
• Email: annika.kruse@uni-graz.at
• Phone: 00433163802329

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.