Understanding lung injury caused by ventilators in elderly patients

Mechanism Study Under the Role of Tissue Kallikrein-related Peptidase 8 (KLK8)-Induced Senescence of Pulmonary Vascular Endothelial Cells in Ventilator-induced Lung Injury in Elderly People.

This study looks at how age affects lung damage from ventilators in older patients to see if longer use of these machines harms their lungs more.

Quick facts

• Study type: Observational
• Enrollment: 1000 (estimated)
• Sex: All
• Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (other)
• Drugs / interventions: immunotherapy
• Locations: 1 site (Shanghai)
• Trial ID: NCT06367946 on ClinicalTrials.gov

What this trial studies

This observational study investigates the relationship between age and the expression of KLK8 in lung tissues, as well as the correlation between endothelial/epithelial damage and the duration of mechanical ventilation in patients of varying ages. Lung tissues and peripheral blood samples are collected from patients undergoing elective surgeries with mechanical ventilation. Statistical analyses will be performed to identify significant correlations, with a focus on how age and ventilation duration impact lung health. The study aims to enhance understanding of ventilator-induced lung injury in the elderly population.

Who should consider this trial

Good fit: Ideal candidates include elderly patients undergoing elective surgeries with mechanical ventilation who are classified as ASA grade 2-3.

Not a fit: Patients with chronic lung diseases, recent pneumonia, or those who are children or pregnant may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved strategies for preventing lung injury in elderly patients requiring mechanical ventilation.

How similar studies have performed: While there have been studies on ventilator-induced lung injury, this specific focus on age-related factors and KLK8 expression is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Lung tissues from patients with different ages:

   Patients undergoing elective general anesthesia surgery; Patients undergoing partial lung resection with mechanical ventilation; American Society of Anesthesiology (ASA) grade 2-3;
2. Peripheral blood from patients with different ages and duration of mechanical ventilation:

Patients undergoing elective general anesthesia surgery with mechanical ventilation; ASA grade 2-3;

Exclusion Criteria:

1. Lung tissues from patients with different ages:

   Patients with chronic lung diseases (asthma, chronic obstructive pulmonary disease (COPD), pulmonary heart disease, etc.); Patients with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
2. Peripheral blood from patients with different ages and duration of mechanical ventilation:

Patients with chronic lung diseases (asthma, COPD, pulmonary heart disease, etc.); Smoking patients; Patients with hypertension/diabetes/coronary heart disease; Patients with HIV, HBV, HCV, HDV, or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.

Where this trial is running

Shanghai

• Shanghai Xinhua hospital — Shanghai, China (RECRUITING)

Study contacts

• Principal investigator: Lai Jiang, PhD — Department of Anesthesia, Shanghai Xinhua hospital, Shanghai China
• Study coordinator: Lai Jiang, PhD

Conditions: Ventilator-Induced Lung Injury