Understanding lung injury caused by ventilators in elderly patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between age and the expression of KLK8 in lung tissues, as well as the correlation between endothelial/epithelial damage and the duration of mechanical ventilation in patients of varying ages. Lung tissues and peripheral blood samples are collected from patients undergoing elective surgeries with mechanical ventilation. Statistical analyses will be performed to identify significant correlations, with a focus on how age and ventilation duration impact lung health. The study aims to enhance understanding of ventilator-induced lung injury in the elderly population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Lung tissues from patients with different ages:

   Patients undergoing elective general anesthesia surgery; Patients undergoing partial lung resection with mechanical ventilation; American Society of Anesthesiology (ASA) grade 2-3;
2. Peripheral blood from patients with different ages and duration of mechanical ventilation:

Patients undergoing elective general anesthesia surgery with mechanical ventilation; ASA grade 2-3;

Exclusion Criteria:

1. Lung tissues from patients with different ages:

   Patients with chronic lung diseases (asthma, chronic obstructive pulmonary disease (COPD), pulmonary heart disease, etc.); Patients with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
2. Peripheral blood from patients with different ages and duration of mechanical ventilation:

Patients with chronic lung diseases (asthma, COPD, pulmonary heart disease, etc.); Smoking patients; Patients with hypertension/diabetes/coronary heart disease; Patients with HIV, HBV, HCV, HDV, or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.

Where it's running

• Shanghai Xinhua hospital
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Lai Jiang, PhD — Department of Anesthesia, Shanghai Xinhua hospital, Shanghai China
• Study coordinator: Lai Jiang, PhD
• Email: jianglaimz@sina.com
• Phone: 13817719616__

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.