Understanding liver damage and heart health in patients with NAFLD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on non-alcoholic fatty liver disease (NAFLD), a common condition that can lead to serious liver and cardiovascular issues. It aims to identify biochemical factors that predict the progression of liver fibrosis in a large population of NAFLD patients, particularly those with metabolic disorders such as obesity and diabetes. The study will utilize established scoring systems like the NAFLD fibrosis score (NFS) to assess the severity of liver fibrosis and its implications for overall health. By analyzing these factors, the study seeks to enhance understanding of NAFLD's impact on liver and cardiovascular health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 years old or more
* Patients with at least on of the following metabolic disorders

  * Obesity
  * Diabetes
  * Arterial hypertension
  * Dyslipidemia

Exclusion Criteria:

* Average daily consumption of alcohol \>20 g in women and of \>30 g in men (assessed by Alcohol Use Disorders Identification Test, AUDIT;
* presence of hepatitis B surface antigen and antibody to hepatitis C virus;
* positive tests for autoimmune hepatitis;
* cirrhosis and other chronic liver diseases;
* diagnosis of oncological diseases
* concomitant therapy with drugs known to promote liver steatosis (e.g. amiodarone);
* other chronic infectious or autoimmune disease;

Where it's running

• Day Service of Internal Medicine and Metabolic Disorders - Policlinico Umberto I - Sapienza University of Rome
  Rome, Italy Recruiting

Study contacts

• Principal investigator: Daniele Pastori, MD — University of Roma La Sapienza
• Study coordinator: Francesco Baratta, MD, PI.
• Email: francesco.baratta@uniroma1.it
• Phone: +390649972249

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• A project to understand fatty liver disease and its complications

  This study is trying to understand how genetics and lifestyle affect fatty liver disease in people at high risk, by looking at their liver health and heart risks through various tests.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan, Milano · NCT06566105

• Investigating heart disease risk factors in psoriasis patients

  This study is trying to see if certain heart-related markers can help predict heart disease risk in people with psoriasis.

  Recruiting Herlev and Gentofte Hospital · Hellerup, Copenhagne · NCT04950218

• A registry for studying Non-Alcoholic Fatty Liver Disease in Europe

  This study is collecting health information and samples from people with Non-Alcoholic Fatty Liver Disease to learn more about the disease and find better ways to track its progress.

  Recruiting at 33 sites Newcastle University · Antwerp and 36 other locations · NCT04442334

• Examining cardiovascular disease diagnosis and prognosis

  This study is trying to see how different heart diseases affect patients compared to healthy people, by looking at their health details and samples to improve diagnosis and predict future health issues.

  Recruiting University Hospitals, Leicester · Leicester · NCT04388943

• Registry for cardiometabolic risk factors

  This study is testing how different heart and metabolic health factors affect people to help prevent future heart problems.

  Recruiting Austral University, Argentina · Pilar, Buenos Aires · NCT04040777

• Abnormal menstrual bleeding in women on antithrombotic drugs after heart surgery

  This study looks at whether women on blood thinners after heart surgery have abnormal menstrual bleeding and what factors might put some at higher risk.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07870941

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.