Understanding Keratinocyte Function in Skin Diseases
Defects of Keratinocytes Function in Dermatologic Patients Carrying Genetic Variants Involved in NOTCH Signaling
IRCCS Burlo Garofolo · NCT06324552
This study looks at how a specific signaling process in skin cells might be linked to hidradenitis suppurativa and Dowling-Degos disease to better understand these conditions and test new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Sex | All |
| Sponsor | IRCCS Burlo Garofolo (other) |
| Locations | 15 sites (Innsbruck and 14 other locations) |
| Trial ID | NCT06324552 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of NOTCH signaling in keratinocyte function related to hidradenitis suppurativa (HS) and Dowling-Degos disease (DDD). It aims to enhance the understanding of the pathogenesis of these orphan diseases by analyzing gene variants that impair NOTCH signaling. The study will utilize in vitro models derived from patient hair follicles and keratinocyte cell cultures to explore the mechanisms underlying these conditions and test innovative therapies like photobiomodulation.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with hidradenitis suppurativa.
Not a fit: Patients who do not have hidradenitis suppurativa or cannot provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and potential new treatments for hidradenitis suppurativa and Dowling-Degos disease.
How similar studies have performed: While this study focuses on specific gene variants and their effects, similar studies have shown promise in understanding keratinocyte function in skin diseases, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of HS Exclusion Criteria: * no informed consent
Where this trial is running
Innsbruck and 14 other locations
- Medical University Innsbruck — Innsbruck, Austria (COMPLETED)
- Université Libre de Bruxelles — Brussels, Belgium (RECRUITING)
- Université Paris Est-Créteil / INSERM U955- Mondor Institute For Biomedical Research (IMRB) — Créteil, France (ACTIVE_NOT_RECRUITING)
- Centre National de la Recherche Scientifique — Strasbourg, France (ACTIVE_NOT_RECRUITING)
- Dessau Medical Cente — Brandenburg, Germany (NOT_YET_RECRUITING)
- Uniklinik Köln — Cologne, Germany (COMPLETED)
- Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinic — Milan, Italy (RECRUITING)
- Azienda ospedaliero-universitaria pisana — Pisa, Italy (RECRUITING)
- Istituto Dermopatico dell'Immacolata, IRCCS — Roma, Italy (RECRUITING)
- Passion people — Roma, Italy (ACTIVE_NOT_RECRUITING)
- Policlinico Universitario Fondazione A. Gemelli IRCCS — Roma, Italy (RECRUITING)
- Ospedale Maggiore di Trieste — Trieste, Italy (RECRUITING)
- Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" — Trieste, Italy (RECRUITING)
- Ospedale San Bortolo — Vicenza, Italy (RECRUITING)
- Jozef Stefan Institute — Ljubljana, Slovenia (ACTIVE_NOT_RECRUITING)
Study contacts
- Study coordinator: Paola Maura Tricarico, BSc
- Email: paolamaura.tricarico@burlo.trieste.it
- Phone: +39 0403785111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hidradenitis Suppurativa, NOTCH signaling