Understanding immune responses in peanut and tree nut allergies
Exploring the Immunological Basis in the Evolution of Tree Nut and Peanut Allergy During Treatment Care for Understanding Markers and Treatment Targets
This study is testing how the immune system reacts in people with peanut and tree nut allergies to see if it can help create better, personalized treatments for them.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 2 Years to 70 Years |
| Sex | All |
| Sponsor | Luxembourg Institute of Health Government |
| Drugs / interventions | immunotherapy |
| Locations | 2 sites (Luxembourg and 1 other locations) |
| Trial ID | NCT06554691 on ClinicalTrials.gov |
What this trial studies
This observational study aims to measure immune parameters in the blood of participants with peanut and tree nut allergies during oral food challenges and while undergoing oral immunotherapy. The research focuses on identifying immune markers that correlate with clinical reactivity and changes in immune responses. By establishing reliable biomarkers, the study seeks to enhance patient stratification and potentially lead to personalized treatment approaches for food allergies. The findings could improve the management of these allergies and the quality of life for affected individuals.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals over 2 years old who are allergic to peanuts or tree nuts.
Not a fit: Patients with co-existing chronic medical conditions or those unwilling to undergo oral food challenges may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment strategies for patients with peanut and tree nut allergies.
How similar studies have performed: Other studies have explored similar approaches in food allergy management, but this study aims to identify novel biomarkers, making it a potentially innovative contribution to the field.
Eligibility criteria
Show full inclusion / exclusion criteria
For Peanut and Tree nut Allergic participants Inclusion criteria: * More than 2 years * Male or Female * Allergic to peanut (assessed by anamnesis, skin reactivity testing, sera testing for specific IgE) * Sign an Informed Consent Exclusion criteria: * Pregnancy * Less than 2 years of age * Co-existing chronic medical condition such as cardiovascular disorders * Peanut or tree nut-allergic patients/families who are unwilling to undergo oral food challenges The eligible participants will be assigned to the oral immunotherapy (OIT) group but if they are not eligible for OIT based on either on the reasons mentioned below, they will be assigned to the avoidance group. Reasons for ineligibility of OIT : * risk of poor compliance with immunotherapy * lack of understanding of the OIT protocol * uncontrolled asthma * incompatibility with lifestyle (regular intense physical activities, multiple vacations) * unwilling to undergo OIT * long-term or frequent use of non-steroidal anti-inflammatory drugs * multiple nut allergy with no direct clinical benefit of OIT to one nut * co-existing comorbidities such as active systemic autoimmune diseases, active malignancy, eosinophilic esophagitis. For Healthy Controls Inclusion Criteria: * Adults * Male or Female * Sign an Informed Consent * Tolerates any type of nut * No known food allergy Exclusion Criteria: * Pregnancy * Co-existing chronic medical condition such as cardiovascular disorders
Where this trial is running
Luxembourg and 1 other locations
- Centre Hospitalier de Luxembourg — Luxembourg, Luxembourg (Recruiting)
- Clinical and Epidemiological Investigation Center, Luxembourg Institute of Health — Luxembourg, Luxembourg (Recruiting)
Study contacts
- Principal investigator: Annette Kuehn — Luxembourg Institute of Health
- Study coordinator: Annette Kuehn
- Email: annette.kuehn@lih.lu
- Phone: 226970335
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.