Understanding immune responses in COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the role of innate immunity in patients with Chronic Obstructive Pulmonary Disease (COPD). It focuses on the behavior of immune cells, such as alveolar macrophages and neutrophils, in response to bacterial infections that exacerbate the condition. By collecting samples through bronchoscopy and blood donation, researchers will analyze the immune cell metabolism and bactericidal mechanisms in COPD patients compared to healthy volunteers. The goal is to better understand the chronic inflammatory processes in COPD to inform future therapeutic strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

COPD patients:

* COPD patients aged 18-77 years who are GOLD Stage 1 or 2 or 3; for patients undergoing bronchoscopy already for a clinical reason.
* COPD patients aged 18-77 years old who are GOLD Stage 1,2 or 3 for patients who are donating blood only.
* COPD patients aged 18-69 years who are GOLD Stage 1 or 2 for patients undergoing bronchoscopy for research purposes.
* COPD- Defined by radiological investigation of chest either chest X-ray or High-resolution CT scan in previous 12 months
* Ability to provide informed consent

Healthy volunteers:

* Any healthy volunteer aged 18-77 years
* Ability to provide informed consent

Exclusion Criteria:

COPD patients:

* Individuals known to have active malignancy, immunosuppression, diabetes mellitus, chronic kidney disease or hepatic failure.
* Individuals with a history of anaemia
* Individuals who have donated \>250 ml of blood for any reason within the last 6 months
* Individuals who are pregnant or breast feeding.
* Current participation in any other clinical trial, except those directly relating to this cohort and study.
* Individuals who have had a febrile illness or other symptoms of acute infectious illness (respiratory, enteric or soft tissue) within the last 2 weeks
* Individuals who have received a vaccine in the past 2 weeks
* Inability to communicate in English or convey willingness to participate.
* For bronchoscopy - Any significant lung condition that would contra-indicate bronchoscopy including:

active acute lung infection (with the exception of asymptomatic pulmonary colonisation) or malignancy, significant coexisting interstitial lung disease or additional pulmonary diagnosis in addition to COPD.

Healthy volunteers:

* Individuals known to have active malignancy, immunosuppression, diabetes mellitus, chronic kidney disease or hepatic failure
* Individuals with anaemia on the screening full blood count (FBC)
* Individuals who donated \>250 ml of blood for any reason within the last 6 months
* Individuals who are pregnant or breast feeding
* Current participation in any other clinical trial
* Individuals who have had a febrile illness or other symptoms of acute infectious illness (respiratory, enteric or soft tissue) within the last 2 weeks.
* Individuals who have received a vaccine in the past 2 weeks
* Chronic or acute respiratory disease.
* Any chronic medical condition or receipt of regular prescription medication other than the oral contraceptive pill.
* Inability to communicate in English or convey willingness to participate
* For bronchoscopy - Any active lung condition including any lung infection or asthma Any significant abnormality on CXR that would contraindicate bronchoscopy FEV1 \<65% predicted (BTS Guidelines, 2001)

Where it's running

• Royal Infirmary of Edinburgh
  Edinburgh, United Kingdom Recruiting
• University of Edinburgh
  Edinburgh, United Kingdom Not yet recruiting

Study contacts

• Principal investigator: David H Dockrell, MD — University of Edinburgh
• Study coordinator: David H Dockrell, MD
• Email: David.Dockrell@ed.ac.uk
• Phone: +441312426213

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.