Understanding immune response in intensive care patients
Official title: Kinetics of INF-γ Production in Intensive Care Patients-Monitoring of INF-γ in Intensive Care
Run by Assistance Publique - Hôpitaux de Paris · NCT06549374 · Data updated 2026-11-12
This study is trying to see how the immune system responds in intensive care patients after serious injuries or surgeries to find the best ways to boost their immune defense and improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 7 sites (Annecy and 6 other locations) |
| Status | Recruiting |
| Started | April 24, 2025 |
| Main results expected | October 24, 2026 |
| Study ends | October 24, 2026 |
| Registry record updated | May 19, 2026 |
| Trial ID | NCT06549374 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 years or older who are admitted to intensive care after severe trauma, acute respiratory distress, or major surgeries requiring postoperative intensive care.
✕Probably not a fit
Patients who may not benefit from this study include those who are pregnant, have expressed opposition to participation, or have a hemoglobin level below 7g/dl at inclusion.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the production of interferon gamma (IFN-γ) in patients admitted to intensive care following severe trauma, high-risk surgery, or acute respiratory distress. It aims to identify the immunosuppressive phase in these patients through blood sampling and biomarkers, particularly focusing on the expression of Human Leukocyte Antigen (HLA-DR) on monocytes. The study seeks to determine the optimal timing and patient selection for potential immunostimulation therapies to improve immune defense and reduce complications. By understanding these dynamics, the research hopes to enhance patient outcomes in critical care settings.
Why it matters
Potential benefit: If successful, this study could lead to improved identification and treatment strategies for critically ill patients, potentially reducing infection rates and mortality.
How similar studies have gone: While previous studies on IFN-γ have shown mixed results, this approach of using biomarkers to guide treatment timing and patient selection is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 years or older * Patients admitted to intensive care after severe trauma, or presenting with acute respiratory distress, or undergoing cardiac, vascular, or digestive surgery with planned postoperative intensive care. Exclusion Criteria Exclusion Criteria: * Expressed opposition from the patient, a relative (if applicable), or their legal representative (guardian, curator) * Pregnant woman * Hemoglobin less than 7g/dl at inclusion
Where it's running
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Réanimation cardio-chirurgicale - Pitié-Salpêtrière hospital
Paris, Île-de-France Region, France Recruiting -
Réanimation chirurgicale Gaston Cordier - Pitié-Salpêtrière hospital
Paris, Île-de-France Region, France Recruiting -
Reanimation department, Annecy Genevois hospital
Annecy, France Not yet recruiting -
Reanimation department, Clermont-Ferrand Hospital
Clermont-Ferrand, France Not yet recruiting -
Reanimation department, Lyon hospital
Lyon, France Not yet recruiting -
Réanimation chirurgicale Husson Mourrier - Pitié-Salpêtrière hospital
Paris, Île-de-France Region, France Not yet recruiting
Show 1 more location
-
Réanimation neuro-chirurgicale - Pitié-Salpêtrière hospital
Paris, Île-de-France Region, France Not yet recruiting
Study contacts
- Study coordinator: Jean-michel Constantin, MD, PhD
- Email: jean-michel.constantin@aphp.fr
- Phone: 33142161936
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.