Understanding HPV Viral Load and Its Role in Recurrence of High-Grade Cervical Lesions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to investigate the relationship between HPV viral load and the recurrence of high-grade squamous intraepithelial lesions (HSIL) in women. Conducted across multiple centers in China, the study will enroll 4,000 women diagnosed with HSIL, collecting cervical and vaginal samples at baseline and during follow-up visits at 6, 12, and 24 months. The samples will undergo various tests, including PCR-sequencing and HPV testing, to assess the correlation between viral load and disease progression. The findings could provide insights into the predictive value of HPV load for monitoring HSIL recurrence.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 20 and over.
* The result of cervical histopathology in the last 3 months was high-grade squamous intraepithelial lesion (HSIL).
* Non pregnant people with sexual history.
* Asexual life, no vaginal medication or flushing before 72 hours of sampling.

Exclusion Criteria:

* Within 8 weeks after pregnancy or postpartum.
* Patients with history of genital tract tumor.
* History of HPV vaccination.
* Previous history of hysterectomy, cervical surgery, pelvic radiotherapy Historical.
* In recent one month, she has received genital tract infection, HPV or other STDs treatment related to the infection of mycoplasma.
* Use antibiotics or vaginal microecological improvement products in recent 1 month.

Where it's running

• Fujian Maternity and Child Health Hospital
  Fuzhou, Fujian, China Recruiting
• Mindong Hospital of Ningde City
  Ningde, Fujian, China Recruiting
• Ningde Municipal Hospital of Ningde Normal University
  Ningde, Fujian, China Recruiting
• The First Hospital of Putian City
  Putian, Fujian, China Recruiting
• Quanzhou First Hospital Afflicated to Fujian Medical University
  Quanzhou, Fujian, China Recruiting
• Zhangzhou affiliated Hospital of Fujian Medical University
  Zhangzhou, Fujian, China Recruiting

Study contacts

• Study coordinator: Binhua Dong
• Email: dbh18-jy@126.com
• Phone: +86-591-87558732

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Risk of cervical cancer after HPV detection in healthy women

  This study tests how likely it is for cervical cancer to develop after different HPV detection patterns in healthy women who undergo HPV-based screening.

  Recruiting Karolinska Institutet · Stockholm · NCT07850128

• Dysplasix™ intravaginal suppositories for women with high‑risk HPV and mild cervical cell changes

  This trial tests whether nightly Dysplasix™ vaginal suppositories can clear high‑risk HPV and help mild cervical cell changes (ASC‑US or LSIL) in adult women.

  Recruiting Phase 2 Amplexd Therapeutics, Inc. · Shatin, New Territories · NCT07572396

• At-home HPV self-collection kits for cervical cancer screening

  We are testing different ways to give at-home HPV self-collection kits to under-screened people aged 25–65 to see if more of them complete cervical cancer screening and follow-up.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07453459

• Comparing clinic-only versus clinic plus community outreach to offer HPV self-collection for cervical screening in women with HIV

  This project will test whether adding community health worker outreach to clinic services helps more women living with HIV complete HPV self-collection for cervical screening.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Kampala · NCT07428330

• CHW4CervixHealth: HPV self-collection kits with community health workers

  This project will test whether giving self-collection HPV kits during community workshops led by community health workers helps increase screening among under-screened women aged 25–65 and will first compare kit results to clinical Pap smears.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07336134

• Q-Pad menstrual-pad test to detect high-risk HPV and cervical precancer

  This study tests whether a home menstrual-pad kit (Q-Pad) can detect high-risk HPV and cervical precancer in people referred for colposcopy after an abnormal Pap or HPV result.

  Recruiting at 3 sites Qurasense · New Haven, Connecticut and 2 other locations · NCT07281599

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.