Understanding how weight loss affects exercise metabolism in healthy individuals
Adaptations of Exercise Energy Metabolism in Response to Simulated Weight Loss Versus Effective Weight Loss Induced by Diet in Healthy Normal Weight
This study is testing how losing weight affects how healthy people burn energy during exercise.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 1 site (Clermont-Ferrand, Aura) |
| Trial ID | NCT05370222 on ClinicalTrials.gov |
What this trial studies
This study investigates the physiological changes that occur in healthy normal weight individuals in response to weight loss. Participants will undergo a control session followed by randomized exercise sessions on an anti-gravity treadmill, simulating weight loss of 3% and 6%. Additionally, a dietary intervention will be implemented to induce a 6% weight loss. The goal is to gain insights into how exercise energy metabolism adapts during weight loss.
Who should consider this trial
Good fit: Ideal candidates are healthy adults with a BMI between 18.5 and 24.9 who have maintained stable body weight for at least six months.
Not a fit: Patients with a BMI outside the normal range, high levels of physical activity, or any comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into how weight loss affects metabolism, potentially guiding dietary and exercise recommendations for healthy individuals.
How similar studies have performed: While there is ongoing research in this area, this specific approach of simulating weight loss during exercise in healthy individuals is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Body mass index (BMI) between 18.5 and 24.9 kg/m², * Subjects abled to understand the information note and abled to sign the consent form, * Subjects with stable body weight (variation \< 3% of body weight) until at least 6 months, * Subjects subjected to a social security plan. Non-Criteria: * Have achieved a minimal BMI \< 18.5 or maximal BMI ≥ 25 kg/m² in adult life, * Subjects with high levels of physical activity (\> 5 h of exercise per week), * Presence of comorbidities or medical conditions that may interfere with study data, * Subjects undergoing energy restriction or physical activity weight loss program at the time of inclusion or within the past 6 months, * Taking medication that may interfere with study results, * Surgery within the last 3 months, * Person under guardianship, curatorship, or safeguard of justice; or not subject to a social security plan, * Pregnant or breastfeeding women, * Refusal to sign the consent form, * Person in a period of exclusion from another study, * Regular consumption of tobacco or alcohol, * Voluntary weight loss in the last 6 months, * Present or past eating disorders.
Where this trial is running
Clermont-Ferrand, Aura
- CHU Clermont-Ferrand — Clermont-Ferrand, Aura, France (Recruiting)
Study contacts
- Study coordinator: Lise Laclautre
- Email: promo_interne_drci@chu-clermontferrand.fr
- Phone: 04 73 75 11 95
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.