Understanding how polyphenols are processed in people with an ileostomy
Official title: Investigation of in Vivo Endogenous and/or Exogenous Production of Phenolic Metabolites in People With an Ileostomy Using an Oral (Poly)Phenol Challenge Test
Run by University of Ulster · NCT07772362 · Data updated 2026-11-12
Researchers will test how small amounts of plant polyphenols are absorbed and transformed in people living with an ileostomy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of Ulster Academic / other |
| Locations | 1 site (Coleraine) |
| Status | Recruiting |
| Started | August 2026 |
| Main results expected | May 2028 |
| Study ends | May 2028 |
| Registry record updated | August 19, 2026 |
| Trial ID | NCT07772362 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal participants are adults aged 18-75 living with an ileostomy for more than one year, without recent antibiotic or phytochemical supplement use, and able to attend testing visits.
✕Probably not a fit
Individuals without an ileostomy or those not meeting the health or lifestyle criteria may not experience the same information about polyphenol metabolism.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines how different polyphenol-rich capsules are absorbed and metabolized in individuals with an ileostomy. Volunteers will take (poly)phenol capsules and undergo testing to measure small intestine absorption and the resulting metabolites. The goal is to map how absorption, metabolism, and excretion vary between people and to identify factors that drive these differences. Results may improve understanding of how diet affects heart and metabolic health in this population.
Why it matters
Potential benefit: If successful, the study could clarify which polyphenol-derived compounds circulate in the body after ileostomy and how to optimize dietary strategies for cardiometabolic health.
How similar studies have gone: Prior research shows inter-individual variability in polyphenol metabolism; this study extends understanding specifically in ileostomy patients, which is a novel focus.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Currently living with an ileostomy * \> 1-year post-operative * Aged 18 - 75 years * BMI 18 - 28 kg/m2 * Males and females (not currently pregnant / lactating) * Non-smokers (including vaping) * Not taking antibiotic therapy 3 months prior to the study * No phytochemical supplement usage 2 weeks prior to study start. * Free-living (i.e. not housebound) * No participation in other biomedical studies 3 months prior. Exclusion Criteria: * Not currently living with an ileostomy * Ileostomy formed \< 1 year previously * Not aged 18 - 75 years * BMI \<18 or \>28 kg/m2 * Pregnant / lactating female * Smokers (including vaping) * Those taking antibiotic therapy 3 months prior to the study * Phytochemical supplement usage within 2 weeks of study start. * Housebound or otherwise unable to attend testing visits. * Participation in a biomedical study (3 months prior to study start).
Where it's running
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Ulster University, Human Intervention Studies Unit, Coleraine, Co. Londonderry, BT521SA
Coleraine, United Kingdom Recruiting
Study contacts
- Study coordinator: Chris IR Gill, PhD
- Email: c.gill@ulster.ac.uk
- Phone: +44 28 7012 3181
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This tests whether a teach-back stoma education program helps adults with a new colostomy or ileostomy feel more confident and manage their stoma better.
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This study will test whether commonly used psychotropic medicines and newer oral blood thinners reach expected levels in adults who have an ileostomy or colostomy.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.